Review
Published
Strategic roadmap for FAIR-compliant transcriptomic workflows: from technical challenges to bioinformatics democratization
Verónica Jiménez Jacinto · Leticia Vega-Alvarado
Frontiers in Bioinformatics
doi 10.3389/fbinf.2026.1882808
Library
Articles
Every article on Frontiers is peer reviewed, permanently archived and free to read.
Showing 35 articles
Original Research
Published
The arginine repressor ArgR controls virulence factors of adherent-invasive Escherichia coli strains
Queralt Bonet-Rossinyol · Margarita Martinez-Medina · Llorenç Fernández-Coll
Frontiers in Cellular and Infection Microbiology
doi 10.3389/fcimb.2026.1941024
Original Research
Published
Comparative transcriptomic analysis reveals the protective mechanism of ferulic acid against lipopolysaccharide-induced ferroptosis in IPEC-J2 cells
Jiayu Chen · Hongchao Li · Yaxuan Niu · Tao Guo · Xiangyu Wang · Yue Zhang · Wenwen Wang · Yuanqing Xu · Yuan Wang · Mingxing Chu
Frontiers in Veterinary Science
doi 10.3389/fvets.2026.1950560
Original Research
Published
Diffusible signals from Azospirillum brasilense promote rice growth and induce distinct gene expression changes in plant roots
Samuel Hoggard · Matthew Calhoun · Anna Bommes · Yasir Rahmatallah · Dylan Neuhaus · Galina Glazko · Arijit Mukherjee
Frontiers in Plant Science
doi 10.3389/fpls.2026.1911178
Original Research
Published
Genome-wide analysis of the GATA gene family in Castanea mollissima reveals key regulators involved in salt stress response
Xiangyu Wang · Xili Liu · Jun Liu · Le Niu · Huoqiang Quan · Tong Zhang · Qinuo Li · Guoyun Zhang · Liyang Yu
Frontiers in Plant Science
doi 10.3389/fpls.2026.1907055
Original Research
Published
Integrative single-cell and bulk transcriptomic analysis identifies monocyte/macrophage senescence-associated candidate genes in pulmonary arterial hypertension
Xiaojun Chen · Weibin Wu · Yilong Liu · Guili Lian · Qingquan Liu
Frontiers in Immunology
doi 10.3389/fimmu.2026.1938985
Original Research
Published
Selective inhibition of aldosterone production modulates human adrenocortical (HAC15) cell fate
Kha Chin Long · Amnani Aminuddin · Najiah Ajlaa Ayub · Geok Chin Tan · A. Rahman A. Jamal · Nor Azian Abdul Murad · Nor Adzimah Johdi · Celso E. Gomez-Sanchez · Norlela Sukor · Morris J. Brown · Elena A. Azizan
Frontiers in Endocrinology
doi 10.3389/fendo.2026.1872432
Original Research
Published
Study on the promoting effect of microplastic exposure on prostate cancer migration and invasion based on network toxicology and single-cell sequencing technology
Haiyang Jiang · Ying Bi · Longguo Dai · Yong Zhu · Ruikang Zhang · Chen Hu · Hong Yang · Jun Li · Chongjian Zhang · Yu Bai · Ruiqian Li
Frontiers in Oncology
doi 10.3389/fonc.2026.1973812
Original Research
Published
Distinct temporal trajectories of EPAS1 mRNA expression during moderate-altitude training in Han and Tibetan endurance athletes
Qing-Qing Su · Hai-Lin Ma · Yan-Lin Sun · Fu-Hai Ma · Yan-Chang Shen · Jian Wang · Xiao-Wei Ma · Jiang-Long Zhang · Yang Zhang · Erik R. Swenson
Frontiers in Cell and Developmental Biology
doi 10.3389/fcell.2026.1973797
Original Research
Published
Histopathology-guided spatial transcriptomic analysis identifies an ECM-associated stromal pattern in lacrimal gland adenoid cystic carcinoma with complementary proteomic and functional analyses
Rong Luan · Difei Zuo · Yeqing Wang · Meixia Jiang · Xun Liu · Limin Zhu · Tingting Lin
Frontiers in Pharmacology
doi 10.3389/fphar.2026.1949721
Original Research
Published
Thioredoxins as hormone-responsive redox regulators in wheat: transcriptomic and structural insights
Mohammed Hashim Bouzenita · Rana Adnan Tahir · Mengjie Fan · Aisha Shabib Estanbooli · Kamel Chibani
Frontiers in Plant Science
doi 10.3389/fpls.2026.1911123
Original Research
Published
A light-responsive engineered probiotic system to alleviate anxiety via gut-brain axis
Yuling Chang · Zhaofang Hang · Yuhan Zhang · Yuhao Zhu · Xingang Li · Xuejun Wang · Di Zhang
Frontiers in Bioengineering and Biotechnology
doi 10.3389/fbioe.2026.1864003
Original Research
Published
A zebrafish model of NEXMIF-related encephalopathy identified drivers of hyperlocomotion and provides a scalable platform for drug discovery
Beatriz Bernal-Bermúdez · Francisco J. Martínez-Morcillo · Inmaculada Fuentes-Martínez · Alicia Martínez-López · María L. Cayuela · Victoriano Mulero · Diana García-Moreno
Frontiers in Cell and Developmental Biology
doi 10.3389/fcell.2026.1899363
Original Research
Published
Identification of microglia-associated hub genes and a CX3CR1/P2RY12 two-gene diagnostic model for cross-subtype epilepsy-associated cortical malformations: integrated transcriptomic analysis with external validation
Hongliang Zeng · Bin Li
Frontiers in Neuroscience
doi 10.3389/fnins.2026.1954412
Original Research
Published
Integrating transcriptomic analysis and experimental validation unravels autophagy- and lactylation-related gene signatures in acute myocardial infarction
Jun Peng · Li Chen · Lizhen Liu · Xiangdong Xu · Huiwen Song
Frontiers in Cardiovascular Medicine
doi 10.3389/fcvm.2026.1814910
Brief Research Report
Published
Transcriptomic insights into loperamide-induced gastric dysmotility: RNA-seq analysis of a mouse model
Chunggeon Lee · Seung-Ju Hwang · Young-Su Yang · Bokyung Kim · Dong-Seon Kim · Daeui Park · Chang-Woo Song · Chang-Gue Son
Frontiers in Physiology
doi 10.3389/fphys.2026.1924065
Original Research
Published
Transcriptomic analysis identifies candidate molecular mechanisms underlying SCF+G-CSF-reduced neuropathology in aged APP/PS1 mice
Afua Addo · Bin Li · Sasidhar Murikinati · Robert Gardner · Li-Ru Zhao
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1705436
Original Research
Published
Integrating transcriptomic analysis to explore biomarkers and therapeutic targets for rheumatoid arthritis: a case-control and systems biology approach
S. Aswini · S. Mohamed Muzammil · N. Raja · S. Asha Devi
Frontiers in Bioinformatics
doi 10.3389/fbinf.2026.1891543
Original Research
Published
Isogenic human stem cell models reveal mutation-dependent protective mechanisms of APOE3 Christchurch
Carlye Frisch · Lauren Baker · Gayathri Srinivasan · Albert E. Mintah · Salma Leyasi · Morgan Pedroza · Brooke Galyon · David A. Brafman
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1856154
Review
Published
Mitochondrial metabolic plasticity in cancer: hybrid bioenergetic states and translational targeting in surgical oncology
Debdeep Chattopadhyay · Ramya Lakshmi Rajendran · Nida Mubin · Durva Tendulkar · Thoudam Debraj Singh · Subhrojyoti Ghosh · Saurabh Kumar Jha · Prakash Gangadaran · Byeong-Cheol Ahn
Experimental Biology and Medicine
doi 10.3389/ebm.2026.11244
Original Research
Published
Single-cell transcriptomic analysis identifies vascular smooth muscle cell transcriptional programs associated with human carotid plaque remodeling
Yi-Jie Lu · Xue-Guang Lin · Ting Wang · Fan-Xuan Huang · Ying Deng · Shuai Jiang · Jing Dong Tang · Bo Yu
Frontiers in Molecular Biosciences
doi 10.3389/fmolb.2026.1950061
Technology and Code
Published
singIST: an R/bioconductor library and quarto dashboard for automated single-cell comparative transcriptomics analysis of disease models and humans
Aitor Moruno-Cuenca · Sergio Picart-Armada · Alexandre Perera-Lluna · Francesc Fernández-Albert
Frontiers in Genetics
doi 10.3389/fgene.2026.1952333
Original Research
Published
Integrated microarray-based and single-cell transcriptomic analyses reveal cell adhesion-related fibrotic remodeling signatures in heart failure
Shun Zhang · Le Li · Zuohua Li · Xiaojun Wang · Juan Zhou · Qing Lyu
Frontiers in Molecular Biosciences
doi 10.3389/fmolb.2026.1929610
Original Research
Published
In silico transcriptomic analysis nominates TSPAN32 as a central node of SCFA-driven immunometabolic reprogramming in intestinal epithelial cells
Zahra Masood · Iqra Sarwar · Ayesha Sanam · Amber Zaidi · Muhammad Zulfiqah Sadikan
Frontiers in Bioinformatics
doi 10.3389/fbinf.2026.1847552
Original Research
Published
Alternative splicing remodeling and splicing factor regulatory networks define immune-associated molecular heterogeneity in dilated cardiomyopathy
Jia Li · Yiyu He · Xianxian Zhao · Zhifu Guo · Jinchao Song · Xiaowei Song
Frontiers in Bioinformatics
doi 10.3389/fbinf.2026.1934275
Original Research
Published
Transcriptomic analysis of Hericium erinaceus mycelia at distinct growth stages: insights into molecular mechanisms underlying mycelial proliferation
Hailong Zong · Yuhan Duan · Xiaolei Li · Hongchun Bao
Frontiers in Fungal Biology
doi 10.3389/ffunb.2026.1778644
Original Research
Published
Comparative transcriptomic analysis of functional and metabolic changes in mass-reared and wild Anastrepha ludens Loew (Diptera: Tephritidae)
Carlos Eduardo Aguilar-Castillo · Obdulia Lourdes Segura-León · Juan Cibrián-Tovar · Héctor González-Hernández · Juan Núñez-Farfán · Brenda Torres-Huerta
Frontiers in Insect Science
doi 10.3389/finsc.2026.1913379
Brief Research Report
Published
Spatial transcriptomic analysis of kidney biopsies identifies activation of complement and SPP1 networks in Staphylococcus infection-associated glomerulonephritis
Spyros Karaiskos · Luis Santana-Quintero · Cherri Bott · Rahul Paul · Sergey V. Brodsky · Isabelle Ayoub · Samir V. Parikh · Brad H. Rovin · Tibor Nadasdy · Hira L. Nakhasi · Sreenivas Gannavaram · Anjali A. Satoskar
Frontiers in Nephrology
doi 10.3389/fneph.2026.1863912
Original Research
Published
Virtual screening and mechanistic elucidation of myricetin as a quorum sensing inhibitor targeting AhyI in Aeromonas hydrophila
Bingxin Li · Qiyu Gu · Boqiang Wei · Hui Geng · Li Xiong
Frontiers in Aquaculture
doi 10.3389/faquc.2026.1815299
Original Research
Published
ETH and Burs-α are necessary for the normal molting in Dalbulus maidis and Delphacodes kuscheli
Nicolás Luján Andrada · Mariana Crespo · Agustin Ariel Baricalla · Lucia Inés Dalaisón-Fuentes · Marcos Sterkel · Maria Inés Catalano
Frontiers in Insect Science
doi 10.3389/finsc.2026.1811933
Original Research
Published
Regulation of Nosema ceranae gene expression by Bidens pilosa phytogenic treatment in infected honey bees
Yi-Hsuan Li · Kai-Di Chen · Ju-Chun Chang · Zih-Ting Chang · Chong-Yu Ko · Shang-Tse Ho · Li-Hung Chen · Ming-Cheng Wu · Wen-Chin Yang · Yu-Liang Yang · Yue-Wen Chen · Yu-Shin Nai
Frontiers in Insect Science
doi 10.3389/finsc.2026.1828903
Original Research
Published
Priming tomato with AgNPs coated with Pseudomonas N5.12 metabolites enhances plant resilience to drought stress
Svitlana Plokhovska · Ana García-Villaraco · Jose Antonio Lucas · Enrique Gutierrez-Albanchez · Francisco Javier Gutierrez-Mañero · Beatriz Ramos-Solano
Frontiers in Nanotechnology
doi 10.3389/fnano.2026.1771931
Original Research
Published
Transcriptomic analysis reveals differential gene expression and metabolic reprogramming in Coptis teeta Wall. under drought and heat stress
Manabendra Nath · Dip Kumar Bhattacharjya · Preetom Regon · Dikshit Goswami · Khirod Kalita · Kunal Boro · Bikash Kumar Kundu · Bhaben Tanti
Frontiers in Plant Physiology
doi 10.3389/fphgy.2025.1715857
Neuroscience
Published
Modulation of neural activity and gene expression by arecoline
Xiaonan Li · Jie Gao · Xiaomin Liu · Jianfeng Guo · Yifan Liu · Peicai Cui · Dawei Yan · Ting Fei · Ming Chen · Yihan Gao
Frontiers in Integrative Neuroscience
doi 10.3389/fnint.2025.1545260
Analytical Science
Published
Metatranscriptomic analysis of tomato rhizospheres reveals insight into plant-microbiome molecular response to biochar-amended organic soil
Seanna Hewitt · Rishikesh Ghogare · William Troxel · Elvir Tenic · Daylen Isaac · Amit Dhingra
Frontiers in Analytical Science
doi 10.3389/frans.2023.1205583