Articles | Frontiers

Original Research

Published 9 October 2026

Sex-dependent transcriptional and imaging responses to metformin in young-adult mice with SuHx-induced pulmonary arterial hypertension

Irene Fernández-Folgueral · María Jesús Sánchez-Guisado · Irati Aiestaran-Zelaia · Marta Beraza · Aitor Zubillaga-Unsain · Claudia Miranda-Pérez de Alejo · Amanda Marrero-Pérez de Alejo · Kinsey Mae Thorpe · Angela Frimpong · Rui Adão · Ian J. Holt · Jesús Ruiz-Cabello

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2026.1947678