Review
Published
A review on advances in chemical compound toxicology prediction
Ahmed Hagag · Nada A. Elsayed · Ibrahim Abdelbaky
Frontiers in Bioinformatics
doi 10.3389/fbinf.2026.1974935
Library
Articles
Every article on Frontiers is peer reviewed, permanently archived and free to read.
Showing 44 articles
Review
Published
Epigenetic rewiring of immunological memory in cancer: heterogeneity, mechanisms, and therapeutic vulnerabilities
Wenna Liu · Xiaole Pan · Yujia Zhao · Zhimei Li · Dan Wu · Ying Liang
Frontiers in Immunology
doi 10.3389/fimmu.2026.1890189
Original Research
Published
Direct RNA sequencing-based multi-omics profiling reveals transcriptional and post-transcriptional remodeling in mice with diet-induced atherosclerosis
Xin Liu · Xueyu Han · Wenjun Qiu · Fengming Guo · Yan Guo · Yipeng Gao · Yuxin Liu · Ruichen Xu · Ke Hu · Bo Shen
Frontiers in Cell and Developmental Biology
doi 10.3389/fcell.2026.1953461
Original Research
Published
Amomum tsao-ko volatile oil alleviates renal fibrosis in 5/6 nephrectomy rats through TGF- β 1/SMAD3 and PI3K/AKT signaling pathways
Huanyue Cui · Meiru Shi · Qing Xu · Shangwen Zhou · Xin Li · Hangyu Wang · Dahong Yao · Ke Zhang · Pinghua Sun · Jinhui Wang
Frontiers in Pharmacology
doi 10.3389/fphar.2026.1819932
Original Research
Published
Availability and reimbursement of fixed-dose combination medicines for hypertension treatment in Central and Eastern Europe
Rafał Nowak · Przemysław Holko · Iris Hoxha · Alexandra Savova · Pero Draganić · Jana Skoupa · Agnes Männik · Zoltán Kaló · Arturs Praskilevics · Kristina Garuoliene · Ljubica Shuturkova · Elena Chitan · Natasa Duborija-Kovacevic · Michał Owca · Ioana Bianchi-Manaila · Nikola Stefanovic · Tomas Tesar · Tamás Ágh · Paweł Kawalec
Frontiers in Pharmacology
doi 10.3389/fphar.2026.1889485
Review
Published
Artificial intelligence - driven toxicogenomics for predictive environmental and pharmaceutical safety
Mohammed Monirul Islam · Sibghatullah Muhammad Ali Sangi · Girish Meravanige · Sreeharsha Nagaraja · Muhammad Shahzad Chohan · Md Khalid Anwer · Ashesh Gurung
Frontiers in Genetics
doi 10.3389/fgene.2026.1858338
Correction
Published
Correction: Multi-homosubunit dsRNA/ dsDNA virus genome packaging nanomotors with sequential revolving mechanisms for potent drug development
Frontiers Production Office
Frontiers in RNA Research
doi 10.3389/frnar.2026.2009050
Hypothesis and Theory
Published
The developmental dopamine trajectory hypothesis of ADHD across the lifespan
Raly James Perez Custodio · Stephan Getzmann · Edmund Wascher · Michael C. Pan · Florence Ingred Samante · Fred Lawrence Samante · Bung-Nyun Kim · Hee Jin Kim · Eugene C. Yi · Jae Hoon Cheong
Frontiers in Psychiatry
doi 10.3389/fpsyt.2026.1944446
Review
Published
The potential of AI inspired approaches for patient monitoring in drug development for Huntington’s disease: capturing the digital exhaust for activities of daily living
Amit Khanna · Graham Jones
Frontiers in Molecular Medicine
doi 10.3389/fmmed.2026.1966010
Review
Published
New insight into Alzheimer’s disease: small molecule-Aβ in the brain transport and peripheral organ clearance
Tianci Ma · Yongyi Li · Yuting Ding · Shijie Liu · Chuanhao Gao · Xiang Li · Zhiqian Tong · Yan Lv
Frontiers in Aging
doi 10.3389/fragi.2026.1921485
Original Research
Published
Quadrimodal in vivo assay for detection of adverse neuro-behavioral effects: validation using dextromethorphan
Günther K. H. Zupanc · Abigail L. Zodl · Naya M. Sabha
Frontiers in Drug Discovery
doi 10.3389/fddsv.2026.1917655
Brief Research Report
Published
R2Tg retrotransposon mediated targeted integration of exogenous genes into the 28S rDNA locus in mammalian cell lines for PKU gene therapy
Xiuyuan Wang · Ziqi Wen · Rongjun Xu · Wenjing Shi · Yiling Long · Xingri Zhan · Rui Su · Jia Fei · Yumin Li
Frontiers in Genome Editing
doi 10.3389/fgeed.2026.1893815
Review
Published
Animal reuse in safety assessment studies: a review of current practices, challenges and 3Rs opportunities
John S. Kendrick · David A. Shaw · Marie Jourdain · Claudia Senn · Helen Beyer · Fiona R. Sewell
Frontiers in Toxicology
doi 10.3389/ftox.2026.1854281
Review
Published
Quantum computing in drug discovery
Harshraj Gadbail · Rajendra Rewatkar · Nishant Jumde · Mrinal Manker · Pratik Nagre · Sujal Zade
Frontiers in Drug Discovery
doi 10.3389/fddsv.2026.1815176
Original Research
Published
A practical approach for regulatory acceptance of virtual control groups: vehicle pooling and biological relevance assessment
Jiwon Kim · Yoongi Kim · Daeui Park · Sang Kyum Kim · Myung-Gyun Kang
Frontiers in Toxicology
doi 10.3389/ftox.2026.1888158
Review
Published
Multi-homosubunit dsRNA/dsDNA virus genome packaging nanomotors with sequential revolving mechanisms for potent drug development
Margaret Bohmer · Justin Gnarra · Daniel W. Binzel · Tao Weitao · Peixuan Guo
Frontiers in RNA Research
doi 10.3389/frnar.2026.1870177
Original Research
Published
In silico prediction of the permeability of phytochemicals across the blood-brain barrier
Diogo Carregosa · Iris Moreira · Diogo Rasteiro · Leonardo Vanneschi · Cláudia Nunes dos Santos
Frontiers in Drug Discovery
doi 10.3389/fddsv.2026.1939611
Review
Published
Oral absorption of high molecular weight polyethylene glycols: mechanistic, safety and regulatory insights
Chiara G. M. Gennari · Sara Azari · Antonella Casiraghi · Umberto M. Musazzi
Frontiers in Drug Safety and Regulation
doi 10.3389/fdsfr.2026.1851318
Review
Published
A survey of LLMs in drug discovery and precision medicine
Hasi Hays · William J. Richardson
Frontiers in Drug Discovery
doi 10.3389/fddsv.2026.1854899
Brief Research Report
Published
Navigating imaging artifacts: challenges with visualizing intrinsically fluorescent antimalarials
Emily K. Bremers · David Anaguano · Paul R. Carlier · Vasant Muralidharan · Maria Belen Cassera
Frontiers in Parasitology
doi 10.3389/fpara.2026.1919904
Review
Published
Secreted proteins of Mycobacterium tuberculosis as therapeutic targets for drug discovery
Anthony Musaazi Kaweesa · Divya Tiwari
Frontiers in Tuberculosis
doi 10.3389/ftubr.2026.1736139
Editorial
Published
Editorial: Grey matters in the lab: utilizing human brain tissue for basic research, disease modeling and drug development
Viktor Szegedi · Danqing Yang · Dirk Feldmeyer · Karri Lamsa
Frontiers in Synaptic Neuroscience
doi 10.3389/fnsyn.2026.1910520
Methods
Published
The PATHFAST TB LAM Ag assay: a validated protocol for quantitative tuberculosis treatment monitoring
Yassir Adam Shuaib · Stéphane Coisne
Frontiers in Antibiotics
doi 10.3389/frabi.2026.1844052
Review
Published
Targeting notch signaling pathway in esophageal cancer: from molecular insights to therapies
Sangita Bhattacharyya · Hindole Ghosh · Ameer Hamza · Bernhard Biersack · Gregory N. Gan · Prateek Sharma · Prasad Dandawate
Oncology Reviews
doi 10.3389/or.2026.1709219
Review
Published
Physical feasibility gating in early drug discovery: a decision framework for identifying predictable physical failures, with retrospective illustration
Sarfaraz K. Niazi
Frontiers in Drug Discovery
doi 10.3389/fddsv.2026.1799663
Mini Review
Published
Pairwise learning for molecular property prediction and optimization
Zachary Fralish · Daniel Reker
Frontiers in Drug Discovery
doi 10.3389/fddsv.2026.1859068
Original Research
Published
Detection and characterization of functional (side-)effects of diphenhydramine in the central nervous system using a neuro-behavioral assay: proof of concept
Günther K. H. Zupanc · Hyeseo Hong
Frontiers in Drug Discovery
doi 10.3389/fddsv.2026.1833888
Review
Published
Structural insights into cannabinoid receptors CB1 and CB2: determinants of ligand selectivity
Ann Varghese · Jie Liu · Wenjing Guo · Tucker A. Patterson · Huixiao Hong
Frontiers in Chemical Biology
doi 10.3389/fchbi.2026.1830007
Review
Published
Research overview—2025: integrating scientific progress to accelerate global tuberculosis elimination
Patrick K. Moonan · Timothy H. Holtz
Frontiers in Tuberculosis
doi 10.3389/ftubr.2026.1805962
Review
Published
From biosimilars to breakthroughs: regulatory convergence toward evidence-efficient development of monoclonal antibodies
Sarfaraz K. Niazi
Frontiers in Drug Discovery
doi 10.3389/fddsv.2026.1778468
Review
Published
Neuro-regulatory drug discovery (NRGDD): a neural-circuit framework for systemic therapeutic modulation
Sarfaraz K. Niazi
Frontiers in Drug Discovery
doi 10.3389/fddsv.2026.1782364
Original Research
Published
The database of peptide medications for human deep-space missions demonstrates the potential for on-demand “Astropharmacy”
Rebecca C. Blum · Dorra Omrani · Alina Kunitskaya · Jessica E. Snyder · Cynthia Bui · Philip M. Williams · David J. Loftus · Lynn J. Rothschild
Frontiers in Space Technologies
doi 10.3389/frspt.2025.1692554
Mini Review
Published
Standardization of canine infections for the development of antileishmanial drugs
A. I. Olías-Molero · M. J. Corral-Caridad · M. D. Jiménez-Antón · M. Mateo-Barrientos · J. Carrión · J. J. Torrado · J. M. Alunda
Frontiers in Drug Discovery
doi 10.3389/fddsv.2026.1754269
Mini Review
Published
Zebrafish models for neurological disorders: a platform for natural product-based drug discovery
Anamica Chauhan · Thiyagarajan Raviraj · Ranbir Chander Sobti · Arpan Dutta · Monu Kumar Shukla · Michal Korinek
Frontiers in Natural Products
doi 10.3389/fntpr.2025.1679580
Molecular Medicine
Published
Antibody-drug conjugates targeting the cadherin, claudin and nectin families of adhesion molecules
Masuko Katoh · Yohann Loriot · Izuma Nakayama · Akinobu Hamada · Kohei Shitara · Masaru Katoh
Frontiers in Molecular Medicine
doi 10.3389/fmmed.2025.1661016
Impact Journals
Published
Precision cardiovascular medicine: shifting the innovation paradigm
Masanori Aikawa · Abhijeet R. Sonawane · Sarvesh Chelvanambi · Takaharu Asano · Arda Halu · Joan T. Matamalas · Sasha A. Singh · Shizuka Uchida · Elena Aikawa · Alex Arenas · Jean-Luc Balligand · Chiara Giannarelli · Calum A. MacRae · Neil V. Morgan · Cécile Oury · Hendrik Tevaearai Stahel · Joseph Loscalzo
Frontiers in Science
doi 10.3389/fsci.2025.1474469
Parasitology
Published
Guanine derivatives as promising candidates for the development of purine-based antimalarial drugs
Worlanyo Tashie · Harry P. de Koning · Nancy O. Duah-Quashie · Neils B. Quashie
Frontiers in Parasitology
doi 10.3389/fpara.2025.1634209
Analytical Science
Published
Enhancing constituent estimation in nucleic acid mixture models using spectral annealing inference and MS/MS information
Taichi Tomono · Satoshi Hara · Junko Iida · Takashi Washio
Frontiers in Analytical Science
doi 10.3389/frans.2025.1494615
Lab on a Chip Technologies
Published
How organ-on-a-chip is advancing cancer research and oncology - a cancer hallmarks’ perspective
Leela Rani Avula · Piotr Grodzinski
Frontiers in Lab on a Chip Technologies
doi 10.3389/frlct.2024.1487377
Lab on a Chip Technologies
Published
Guiding organs-on-chips towards applications: a balancing act between integration of advanced technologies and standardization
J. Meneses · F. Conceição · A. D. van der Meer · S. de Wit · L. Moreira Teixeira
Frontiers in Lab on a Chip Technologies
doi 10.3389/frlct.2024.1376964
Biophysics
Published
Utilizing surface plasmon resonance as a novel method for monitoring in-vitro P-glycoprotein efflux
Phuong H. Nguyen · Shuolin Cui · Amanda M. Kozarich · Alex Rautio · Arthur G. Roberts · May P. Xiong
Frontiers in Biophysics
doi 10.3389/frbis.2024.1367511
Biomaterials Science
Published
Acute brain injury and nanomedicine: sex as a biological variable
Amberlyn Simmons · Olivia Mihalek · Heather A. Bimonte Nelson · Rachael W. Sirianni · Sarah E. Stabenfeldt
Frontiers in Biomaterials Science
doi 10.3389/fbiom.2024.1348165
Analytical Science
Published
A Bayesian approach for constituent estimation in nucleic acid mixture models
Taichi Tomono · Satoshi Hara · Yusuke Nakai · Kazuma Takahara · Junko Iida · Takashi Washio
Frontiers in Analytical Science
doi 10.3389/frans.2023.1301602
Cell Death
Published
Small heat shock proteins as modulators of cell death in Plasmodium falciparum parasites and its human host
Francisca Magum Timothy · Tawanda Zininga
Frontiers in Cell Death
doi 10.3389/fceld.2023.1322780