MethodsPublished 19 August 2026Open and closed loop differential target multiplexed spinal cord stimulation in patients with persistent spinal pain syndrome type II: protocol for a one year European multicenter cohort study (ENDLESS)Lisa Goudman · Kliment Gatzinsky · Vivek Mehta · Kavita Poply · Ashish Gulve · Iris Smet · Paul Murphy · Dirk Rasche · Georgios Matis · Jan Willem Kallewaard · José Manuel Trinidad · Pasquale De Negri · Philippe Rigoard · ENDLESS consortium · Maarten MoensFrontiers in Pain Researchdoi 10.3389/fpain.2026.1922595