Hypothesis and TheoryPublished 12 October 2026Treating a systemic disease as a local one: failure points of current pancreatic cancer management and a multimodal, biology-guided framework for redesignPatrick E. SewellFrontiers in Oncologydoi 10.3389/fonc.2026.1941793
Hypothesis and TheoryPublished 9 October 2026A SynNotch-PiggyBac gene circuit for inflammation-responsive IL-10 delivery in Alzheimer’s disease: a hypothesis and design frameworkSuhani Gupta · Ronav GuptaFrontiers in Aging Neurosciencedoi 10.3389/fnagi.2026.1866161
ReviewPublished 9 October 2026Gene, microbiome, and anti-aging doping in sport: molecular mechanisms, detection strategies, and implications for sports rehabilitation medicineDiego CotellaFrontiers in Sports and Active Livingdoi 10.3389/fspor.2026.1984895
CorrectionPublished 8 October 2026Correction: Integrating technologies in the clinical practice, from challenges to opportunities: a multicentric feasibility study in children with different neurodevelopmental disabilitiesBenedetta Del Lucchese · Elena Beani · Giada Martini · Veronica Barzacchi · Clara Bombonato · Gloria Mangani · Valentina Menici · Alessandra Bardoni · Rocco Salvatore Calabrò · Ilaria Maria Anna Cardillo · Valentina Di Giusto · Martina Favetta · Francesca Fumagalli · Carlotta Maria Manzia · Emanuela Pagliano · Stefano Parravicini · Francesca Rita Pulvirenti · Chiara Maria Tacchino · Giovanni Cioni · Giuseppina SgandurraFrontiers in Virtual Realitydoi 10.3389/frvir.2026.1953351
ReviewPublished 30 September 2026Gene therapy for non-obstructive azoospermia: therapeutic avenues and translational pathway to clinical applicationMan-Xi Jiang · Tao Jing · Huai L. Feng · Yan ZhuFrontiers in Genome Editingdoi 10.3389/fgeed.2026.1921175
Original ResearchPublished 23 September 2026Systemic responses to intravenous rAAV administration in boys with Duchenne muscular dystrophyBrooke E. Harris · Brooke M. Seldin · Sam C. Towne · Orinda R. Hobson · Eli Zerpa · Victor Prima · H. Lee Sweeney · David W. HammersFrontiers in Molecular Medicinedoi 10.3389/fmmed.2026.1953867
ReviewPublished 22 September 2026Anti-nutritional factors in plant-derived milk: a review on effects and effective reduction methodsNutakki Govardhini · Sonia Morya · Farhang Hameed Awlqadr · Mohammed Noori Saeed · Ralf Weiskirchen · Qausar Hamed ALKaisy · Ammar B. Altemimi · Muhammad Tauseef Sultan · Hassan RazaFrontiers in Food Science and Technologydoi 10.3389/frfst.2026.1935548
Brief Research ReportPublished 15 September 2026R2Tg retrotransposon mediated targeted integration of exogenous genes into the 28S rDNA locus in mammalian cell lines for PKU gene therapyXiuyuan Wang · Ziqi Wen · Rongjun Xu · Wenjing Shi · Yiling Long · Xingri Zhan · Rui Su · Jia Fei · Yumin LiFrontiers in Genome Editingdoi 10.3389/fgeed.2026.1893815
ReviewPublished 10 September 2026Clinical translation of CRISPR-Cas9 therapeutics in cancer and inherited genetic disordersKhushi Bashir · Prathiksha Vasudev · Vikas Chhetri · Devika Prasad Dubhashi · Yash Gurunath Teli · Rhitam Biswas · Sudha Ramaiah · Anand AnbarasuFrontiers in Genome Editingdoi 10.3389/fgeed.2026.1868779
ReviewPublished 10 September 2026Advancements in CRISPR-based in vivo gene therapy for hemophiliaXiaoyu Zhang · Kaidi Xu · Shihui Zou · Zhiyao Zhu · Shuzhi Teng · Ping HuangFrontiers in Genome Editingdoi 10.3389/fgeed.2026.1924733
ReviewPublished 3 September 2026Hyaluronidase-enhanced delivery in gene therapy and regenerative medicine for improved vector, cell, and cargo accessPatrick E. Sewell · Christopher JensenFrontiers in Drug Deliverydoi 10.3389/fddev.2026.1906950
Hypothesis and TheoryPublished 27 August 2026Grip strength as a systems biomarker of aging: neuromuscular junction constraints and biomarker decoupling in gene therapyPatrick E. Sewell · Christopher JensenFrontiers in Agingdoi 10.3389/fragi.2026.1908078
Brief Research ReportPublished 19 August 2026High-titer human packaging cells producing γ-retroviral vectors pseudotyped with engineered baboon endogenous retrovirus (BaEV) envelope proteinsAngelina Hallik · Mona Pißarreck · Mats Jürgen Grummel · Yasemin van Heuvel · Jörn StitzFrontiers in Molecular Medicinedoi 10.3389/fmmed.2026.1888550
Hypothesis and TheoryPublished 24 July 2026The biological memory buffer hypothesis: can programmable nanocarriers shape cellular memory to improve the durability of mRNA vaccines and gene therapies?Okechukwu Paul-Chima Ugwu · Chinyere Nneoma Ugwu · Godson Emeka Anyanwu · Mariam Basajja · Maryann Chiamaka EbuohFrontiers in Drug Deliverydoi 10.3389/fddev.2026.1902184
Frontiers in Science Lead ArticlePublished 25 June 2026Regulatory T cells: master orchestrators of immune tolerance and tissue homeostasisJeffrey A. Bluestone · Megan K. Levings · Frederick J. Ramsdell · Alexander Y. Rudensky · Qizhi Tang · Piotr TrzonkowskiFrontiers in Sciencedoi 10.3389/fsci.2026.1792210
ReviewPublished 26 May 2026CRISPR and Fanzor in sickle cell disease: current progress and future prospectsAisha Yousef Alhumoudi · Aminah Ghazi Alotaibi · Nada Fahad Alosaimi · Abdulrahman Alshalani · Saad M. Alqahtani · Sarah M. Alsaab · Basem Jahz Almutiri · Mohammed M. H. AlbariqiFrontiers in Genome Editingdoi 10.3389/fgeed.2026.1774014
Mini ReviewPublished 26 March 2026Species barriers in AAV tropism: mechanisms, models, and emerging solutions for clinical translationXinyuan XuActa Biochimica Polonicadoi 10.3389/abp.2026.15939
Mini ReviewPublished 25 March 2026Safety and efficacy of novel therapeutics in lupus: a narrative reviewMichael F. Loncharich · Brenna E. Cafeo · Evan B. NobleFrontiers in Lupusdoi 10.3389/flupu.2026.1800946
ReviewPublished 9 February 2026Advances in endothelial cell targeting by AAV vectorsMilena Cichon · Alicja Jozkowicz · Anna Grochot-PrzeczekActa Biochimica Polonicadoi 10.3389/abp.2026.15740
Mini ReviewPublished 6 February 2026Genomic and epigenomic landscape of ADPKD: towards precision diagnostics and tailored treatmentsAmankeldi A. Salybekov · Aiman Kinzhebay · Sumi Hidaka · Shuzo KobayashiFrontiers in Epigenetics and Epigenomicsdoi 10.3389/freae.2026.1699528
Systematic ReviewPublished 3 December 2025CRISPR–Cas9 mediated gene therapy in inherited bone marrow failure syndromesNadeesha J. S. Munugoda Hewa · Rajendra KC · Alex W. Hewitt · Kirsten A. FairfaxFrontiers in Hematologydoi 10.3389/frhem.2025.1713610
ReviewPublished 3 December 2025Advancing AAV vector manufacturing: challenges, innovations, and future directions for gene therapyN. Charan S. S. Kowshik · Pushpendra SinghFrontiers in Molecular Medicinedoi 10.3389/fmmed.2025.1709095
Drug DeliveryPublished 1 July 2025Gene hydrogel platforms for targeted skin therapy: bridging hereditary disorders, chronic wounds, and immune related skin diseasesLiangtao LiFrontiers in Drug Deliverydoi 10.3389/fddev.2025.1598145
Biomaterials SciencePublished 24 February 2025The cutting-edge applications and properties of carbon nanotubes in diagnosis and treatment of lung cancer: a reviewSeyyed Behnam Abdollahi Boraei · Fateme Kamalinejad · Negin KiaeiFrontiers in Biomaterials Sciencedoi 10.3389/fbiom.2025.1500758
Molecular MedicinePublished 9 January 2025Editorial: Gene therapy and genome editing for metabolic liver disordersFanny Collaud · Giulia BortolussiFrontiers in Molecular Medicinedoi 10.3389/fmmed.2024.1543685
Molecular MedicinePublished 27 February 2024Editorial: Celebrating the 200th mendel’s anniversary: gene-targeted diagnostics and therapies for cancerNoah Federman · Erlinda M. Gordon · Sant P. Chawla · Frederick L. HallFrontiers in Molecular Medicinedoi 10.3389/fmmed.2024.1366963
Molecular MedicinePublished 21 September 2023Elaborating the potential of Artificial Intelligence in automated CAR-T cell manufacturingNiklas Bäckel · Simon Hort · Tamás Kis · David F. Nettleton · Joseph R. Egan · John J. L. Jacobs · Dennis Grunert · Robert H. SchmittFrontiers in Molecular Medicinedoi 10.3389/fmmed.2023.1250508