Articles | Frontiers

Original Research

Published 24 September 2026

Comparative effectiveness and safety of topiramate versus amitriptyline for the prophylactic management of chronic migraine: a prospective comparative study

Mohammed Matoog Karami · Amber Hassan · Amal Alkhotani · Mazen Basheikh · Adnan Badahdah · Raed Gasemaltayeb · Ahmed Bamaga · Taghreed Alsinani · Rakan Bokhari · Abdulrahman Almazrooa · Siti Sarah Maidin · Humaira Waseem · Muhammad Anjum · Maher Kurdi

Frontiers in Pain Research

doi 10.3389/fpain.2026.1923623