Articles

Showing 64 articles

• Review

  Published 12 October 2026

  Retinal neurodegeneration as accelerated ocular aging: a review of nutritional and metabolic supplements

  Seyed Mohamadmehdi Moshtaghion · Maryam Shayan · Sarvesh Ramakrishnan · Andrew Ham · Ashkan Shafaei Gharehkoshan · Michael G. Morley · Nazlee Zebardast · Francisco Javier Díaz-Corrales · Enrique Rodríguez de la Rúa · Deeba Husain · Lucia Sobrin · Tobias Elze · David S. Friedman · Mohammad Eslami

  Frontiers in Aging

  doi 10.3389/fragi.2026.1912337

• Editorial

  Published 12 October 2026

  Editorial: Advances in early detection, pathophysiology, and management of mild cognitive impairment

  Edgar Vásquez-Carrasco · Cristian Sandoval-Vásquez · Pablo Valdés-Badilla

  Frontiers in Medicine

  doi 10.3389/fmed.2026.2007251

• Mini Review

  Published 9 October 2026

  Molecular mechanisms underpinning cognitive reserve and resilience

  Amber Chen · Sreenithi Bhuvaneshwaran · Yash Akkara · Thomas Burke · Robert Perneczky · Magdalena Sastre

  Frontiers in Aging Neuroscience

  doi 10.3389/fnagi.2026.1957901

• Review

  Published 7 October 2026

  GLP-1 receptor agonists as potential disease-modifying agents in Parkinson’s and Alzheimer’s disease: mechanisms, clinical trial evidence, and the neuroprotection horizon

  Mohamed Alsharif · Omran Shrebaty · Mohammad Ammar Aloudah · Mayar Alqahtani · Raghad Saud Aloubili · Marafi Jammaa Ahmed · Bana Albani · Ahmad El Bana

  Frontiers in Aging Neuroscience

  doi 10.3389/fnagi.2026.1969490

• Original Research

  Published 6 October 2026

  Reduced serum LEFTY2 and disease-dependent biomarker associations in Alzheimer’s disease: an exploratory study

  Wei Wuli · Raymond Y. Lo · Horng-Jyh Harn · Tzyy-Wen Chiou · Yue-Xuan Xu · Yuncin Luo · Ivan Wijaya · Shinn-Zong Lin

  Frontiers in Aging Neuroscience

  doi 10.3389/fnagi.2026.1955495

• Review

  Published 6 October 2026

  The role of vascular pathology in SMA: implications for pathogenesis and treatment

  Simon H. Parson · Hazel Allardyce

  Frontiers in Cellular Neuroscience

  doi 10.3389/fncel.2026.1933459

• Original Research

  Published 5 October 2026

  Atherosclerotic cardiovascular disease risk is associated with AT(N)V neuroimaging biomarkers and cognitive impairment in the health and aging brain study–health disparities cohort

  Kimberly Espejo · Ryan Rulkens · Cellas A. Hayes · Joey A. Contreras

  Frontiers in Aging Neuroscience

  doi 10.3389/fnagi.2026.1874472

• Original Research

  Published 1 October 2026

  Effect of metformin treatment on brain 18F-FDG uptake: a translational study

  Rubén Fernández de la Rosa · Gonzalo Cuesta Domingo · Pedro Nespral · Elena Marcos-Macías · Marta Vaillant · Luis García-García · Miguel Ángel Pozo · Jordi A. Matias-Guiu · María Nieves Cabrera-Martin · Mirjam Brackhan · Pablo Bascuñana

  Frontiers in Radiology

  doi 10.3389/fradi.2026.1917175

• Original Research

  Published 30 September 2026

  Selective autophagy inhibition alleviates oxidative stress-associated neurodegeneration in an AD+CCH model

  Xiaorui Huang · Jufang Chen · Zhicheng Lu · Jie Wang · Xuelian Luo · Qiuyan Qin · Qin Yang · Chongdong Jian · Xuebin Li · Jingwei Shang

  Frontiers in Aging Neuroscience

  doi 10.3389/fnagi.2026.1870441

• Perspective

  Published 30 September 2026

  Neuroimmune phenotypes in brain aneurysms and neurodegenerative diseases

  Francis J. Lauzier · David C. Lauzier

  Frontiers in Neuroscience

  doi 10.3389/fnins.2026.1916561

• Clinical Trial

  Published 29 September 2026

  Influence of a full-spectrum aqueous extract of black cardamom (Amomum subulatum Roxb.) fruits on focus/alertness and executive function: a randomized, double-blind, placebo-and active- controlled, 14-day comparative study in healthy working professionals

  Jestin V. Thomas · M. E. Mohan · Syam S. Das · Nithyanandam Allimuthu · Sheena Devasia · P. A. Aneesa · Krishnakumar Illathu Madhavamenon · Baby Chakrapani Pulikkaparambil Sasidharan

  Frontiers in Neuroscience

  doi 10.3389/fnins.2026.1879347

• Review

  Published 28 September 2026

  High-order chromatin structures mediated by phase separation in cell senescence

  Wenjing Sun · Boxian Li · Zhaoyong Xu · Jing Wang · Jing Cao · Yangzhong Wang · Jiale Wang · Wenbo Gu · Pengjun Xu · Liang Wang · Wenyan Xie

  Frontiers in Molecular Biosciences

  doi 10.3389/fmolb.2026.1896884

• Mini Review

  Published 25 September 2026

  From dynamic condensates to pathological assemblies: the phase behavior of tau and α -synuclein

  Suelen Camargo · Kevin Novelo · Scott D. Ryan

  Frontiers in Molecular Neuroscience

  doi 10.3389/fnmol.2026.1965177

• Original Research

  Published 23 September 2026

  Beyond development: LINX/Islr2 expression and TrkA interaction in the adult nervous system under neuroinflammatory challenge

  Pamela Rosso · Elena Fico · Viviana Triaca · Annamaria Di Criscio · Ari-Pekka Koivisto · Katja Kuokkanen · Mikko Ares · Kaisa Auvinen · Andrii Domanskyii · Johanna Kela · Carina Stenfors · Paola Tirassa

  Frontiers in Molecular Neuroscience

  doi 10.3389/fnmol.2026.1863350

• Original Research

  Published 23 September 2026

  A home-finding task in virtual reality to test entorhinal path integration performance in patients with mild cognitive impairment

  Sarah Philippen · Frederik Folkerts · Annika Hanert · Yasmin Fiedler · Kim Lampe · Julius Rave · Younes Adam Tabi · Robby Schönfeld · Oliver Granert · Felix Woelk · Thorsten Bartsch

  Frontiers in Virtual Reality

  doi 10.3389/frvir.2026.1745650

• Brief Research Report

  Published 17 September 2026

  Assessment of microexon-associated junction usage in Parkinson’s disease and spinocerebellar Ataxia type 3

  Kira Mehnert · Jeannette Hübener-Schmid · Jakob Admard · Vladislav Lysenkov · German Demidov · Chrisovalantou Huridou · Jonasz Jeremiasz Weber · Olaf Riess · Nicolas Casadei

  Frontiers in Molecular Neuroscience

  doi 10.3389/fnmol.2026.1872346

• Review

  Published 15 September 2026

  Mitohormesis linking metabolic dysfunction and neurodegeneration: implications for dementia and therapeutic strategies

  Toshiki Otoda · Hideto Nakajima · Tadateru Takayama

  Frontiers in Molecular Neuroscience

  doi 10.3389/fnmol.2026.1892506

• Original Research

  Published 15 September 2026

  ALDH1/2 deficiency modulates dieldrin-induced dopaminergic neurodegeneration and reactive glial morphometry in male mice

  Omar A. Yanouri · Adam J. Schuller · Savannah M. Rocha · Aidan M. Briggs · Paul A. Martinez · Elizabeth Fernandez · Randy Strong · Xueshu Li · Hans-Joachim Lehmler · Jonathan A. Doorn · Ronald B. Tjalkens

  Frontiers in Toxicology

  doi 10.3389/ftox.2026.1888799

• Editorial

  Published 11 September 2026

  Editorial: Complex network dynamics of cognitive processing in health and disease: current knowledge and future research

  Simone Cauzzo · Camillo Porcaro · Chandan Kumar Behera · Suriya Prakash Muthukrishnan

  Frontiers in Computational Neuroscience

  doi 10.3389/fncom.2026.1976480

• Original Research

  Published 9 September 2026

  Therapeutic potential of Cola nitida against dexamethasone- and scopolamine-induced cognitive and cardiac dysfunction

  Lawrence Dayo Adedayo · Olugbenga S. Michael · Gideon Opeyemi Ayilara · Mayode Elizabeth Olumoroti · Olubayode Bamidele · Saminu Samaila · Ibtihel Dhaya · Nafisat Dasola Akorede · Patrick Oluwole Abolarin · Laurette N. Ofodile

  Frontiers in Behavioral Neuroscience

  doi 10.3389/fnbeh.2026.1803200

• Review

  Published 7 September 2026

  Periodontitis and Alzheimer's disease, common pathways in down syndrome

  Fabio Arriola-Pacheco · Alicia Leonor Pinzón-Té · Rodrigo Serrano-Piña · Bertha Arelly Carrillo-Ávila · Jaime Díaz-Zúñiga · Samanta Melgar-Rodríguez · Víctor Manuel Martínez-Aguilar

  Frontiers in Dental Medicine

  doi 10.3389/fdmed.2026.1930049

• Original Research

  Published 3 September 2026

  Integrative genome-scale metabolic model of GABAergic neurons reveals metabolic signatures across the mild cognitive impairment – Alzheimer disease continuum

  Andrea Angarita-Rodríguez · Johan H. Largo-González · Julián Pérez-Mejía · Daniel Balcazar · Viviana Vargas-López · Jason A. Papin · Andrés Pinzón · Janneth González

  Frontiers in Systems Biology

  doi 10.3389/fsysb.2026.1897648

• Review

  Published 3 September 2026

  The effects of abused drugs on ferroptosis pathways: potential therapeutic targets for substance use disorders

  Tamara Bouchard · Brooke Russell · Liam Liyang Guo · Tina Nguyen · Yan Cheng · Yan Y. Sanders · Ming-Lei Guo

  Frontiers in Cellular Neuroscience

  doi 10.3389/fncel.2026.1899553

• Mini Review

  Published 1 September 2026

  Memory processing in neurodevelopmental disorders: linking behavioral, circuits, and molecular scales

  Sania Sultana · Sougata Ray · Sarbani Samaddar · Sourav Banerjee

  Frontiers in Cellular Neuroscience

  doi 10.3389/fncel.2026.1883287

• Original Research

  Published 31 August 2026

  Evaluating the correspondence of neuropsychological profiles with clinical diagnostic criteria for frontotemporal lobar degeneration and Alzheimer's disease: insights from k -means clustering

  Marie Söntgerath · Simone Cutini · Angelika I. T. Thöne-Otto · Annerose Engel · Frank Regenbrecht · Maryna Polyakova · Karsten Mueller · Nico Scherf · Fabiola Boehm · Sarah Anderl-Straub · Bernhard Landwehrmeyer · Adrian Danek · Janine Diehl-Schmid · Klaus Fassbender · Klaus Fliessbach · Holger Jahn · Holger Kornhuber · Martin Lauer · Johannes Prudlo · Matthis Synofzik · Jens Wiltfang · Markus Otto · Matthias L. Schroeter

  Frontiers in Dementia

  doi 10.3389/frdem.2026.1757680

• Editorial

  Published 31 August 2026

  Editorial: Cellular and animal models of neurodegenerative and neuroinflammatory conditions

  Juan Antonio García-León · Beatriz García-Díaz · David Baglietto-Vargas · Carlos J. Rodriguez-Ortiz

  Frontiers in Cellular Neuroscience

  doi 10.3389/fncel.2026.1961369

• Original Research

  Published 26 August 2026

  Impaired behavioral flexibility and coping strategy shifts in 5xFAD mice in the novel Destruction-Building Test

  Eugenia Ahremenko · Alexander Andreev · Kirill Chaprov · Eduard Korkotian

  Frontiers in Behavioral Neuroscience

  doi 10.3389/fnbeh.2026.1877086

• Review

  Published 24 August 2026

  Exposome influences: a multi-omics perspective on the combined toxic effects of pharmaceuticals and personal care products in Alzheimer’s disease

  İ. İpek Boşgelmez · Beyza Mertaş · Hayrunnisa Deliser

  Frontiers in Toxicology

  doi 10.3389/ftox.2026.1871830

• Review

  Published 20 August 2026

  From metabolism to neurodegeneration: how microglial functional reprogramming drives neurodegenerative diseases

  Qiaoqiao Cui · Ke Zheng · Qiyun Liu · Lizhen Wang · Yixin Liu · Ruifang Bai · Wei Zhang · Junhong Guo · Xueli Chang · Juan Wang

  Frontiers in Molecular Neuroscience

  doi 10.3389/fnmol.2026.1921079

• Review

  Published 20 August 2026

  Microglia-mediated neuroinflammation in Alzheimer’s disease: mechanisms and emerging therapeutic targets

  Lianjing Xu · Ying Zhang · Li Jiang · Jin Feng Xing · Jing Hu · Tianye Lan · Guang Ta

  Frontiers in Cellular Neuroscience

  doi 10.3389/fncel.2026.1902577

• Original Research

  Published 14 August 2026

  Gap junction protein connexin 36 proteostatic mechanisms in photoreceptor cells subjected to excitotoxic stress

  Monika Katan · Klaudia Mróz · Joanna Lewin-Kowalik · Adrian Smędowski

  Acta Biochimica Polonica

  doi 10.3389/abp.2026.16091

  4,342 views

• Systematic Review

  Published 12 August 2026

  Premature and early menopause and neuroimaging biomarkers of neurodegenerative diseases: a systematic review

  Emily Gallmetzer · Elijah Mak · Firat Kara · Burcu Zeydan · Ekta Kapoor · Chrisandra L. Shufelt · Walter A. Rocca · Kejal Kantarci

  Frontiers in Dementia

  doi 10.3389/frdem.2026.1912295

• Correction

  Published 10 August 2026

  Correction: Long-term exposure to air pollution and cognitive function in older adults: a systematic review and meta-analysis

  Frontiers Production Office

  Frontiers in Environmental Health

  doi 10.3389/fenvh.2026.1961359

• Original Research

  Published 15 July 2026

  Shotgun metagenomic analysis reveals taxonomic and functional alterations in the gut microbiome across prodromal and symptomatic Lewy body disease

  Xiaowei Zhao · Stuart J. McCarter · Vinod K. Gupta · Kiera M. Grant · Erik K. St. Louis · Kejal Kantarci · Rodolfo Savica · Max Hill · Helen E. Vuong · Christopher Staley · Bradley F. Boeve · Owen A. Ross · Levi M. Teigen · Jaeyun Sung

  Frontiers in Microbiomes

  doi 10.3389/frmbi.2026.1834726

• Perspective

  Published 14 July 2026

  Modulating the human gut microbiome-host system: a new drug discovery paradigm

  Gonzalo Colmenarejo

  Frontiers in Drug Discovery

  doi 10.3389/fddsv.2026.1898583

• Hypothesis and Theory

  Published 10 July 2026

  Neuroinflammation as a failure of allostatic integrity: a hierarchical-circular model of biological memory for pathogenesis in neurodegenerative and neuropsychiatric diseases

  Samuel Ruesga Mundo

  Frontiers in Systems Neuroscience

  doi 10.3389/fnsys.2026.1888548

• Original Research

  Published 8 July 2026

  A whole-transcriptome analysis of differentially expressed genes, transcripts, and transcript usage in blood samples from Parkinson’s disease patients

  Sulev Koks · Mari Muldmaa · Jack Price · Luke Whiley · Maili Jakobson · Lewis Singleton · Denise Howting · Abigail L. Pfaff · Abha Chopra · Mark Watson · Katrin Sikk · Pille Taba

  Experimental Biology and Medicine

  doi 10.3389/ebm.2026.11099

• Review

  Published 29 June 2026

  The nano-neuro nexus: smart sensors at the frontier of detecting neurodegeneration

  Arpit Mehrotra · Abhilasha Sood · Shraddha Yadav · Aditi D. Raval · S. Renuka Jyothi · Ashok Kumar Sah · Chandan Sharma · Laxmidhar Maharana

  Frontiers in Nanotechnology

  doi 10.3389/fnano.2026.1843615

• Frontiers in Science Lead Article

  Published 25 June 2026

  Regulatory T cells: master orchestrators of immune tolerance and tissue homeostasis

  Jeffrey A. Bluestone · Megan K. Levings · Frederick J. Ramsdell · Alexander Y. Rudensky · Qizhi Tang · Piotr Trzonkowski

  Frontiers in Science

  doi 10.3389/fsci.2026.1792210

• Review

  Published 10 June 2026

  Zinc-binding proteins in Alzheimer’s disease: mechanisms, therapeutic potential, and natural compound interventions

  Riddhi Upadhyay · Susmita Kar · Murugan Sevanan

  Frontiers in Chemical Biology

  doi 10.3389/fchbi.2026.1836070

• Perspective

  Published 9 June 2026

  Emerging role of genipin as a therapeutic in diseases of the peripheral nervous system

  Archie Patel · Nadja Zeltner

  Frontiers in Biomaterials Science

  doi 10.3389/fbiom.2026.1852025

• Review

  Published 3 June 2026

  Post-translational modifications as a regulatory code for tau function in health and disease

  Abigail J. Nordbeck · Bhirisha Sharma · Charles A. Garcia · Jui-Heng Tseng

  Frontiers in Dementia

  doi 10.3389/frdem.2026.1834737

• Perspective

  Published 2 June 2026

  National and international models of involving people with lived experience in dementia policy, advocacy and research

  Ellen Snowball · Robin Casey · Karen Myers Barnett · Sarah Campill · Jan Runar Eliassen · Marion Tur Eliassen · Brian Anderton · Claire Stockwell-Lance · Mary Warbelow · Juanita-Dawne Bacsu · Emma Lanza · Jennifer Bethell

  Frontiers in Dementia

  doi 10.3389/frdem.2026.1816031

• Review

  Published 2 June 2026

  Revisiting the clastosome: a stress-induced nuclear proteolytic compartment of mammalian cells

  Miguel Lafarga · María T. Berciano · Noemí Rueda · Sofía Cardona-Cortés · Olga Tapia

  Frontiers in Neuroanatomy

  doi 10.3389/fnana.2026.1839944

• Original Research

  Published 22 May 2026

  Synaptosomes isolated from cryopreserved MND motor cortex reveal altered calcium handling and reduced complex IV–linked respiration

  Sean D. Morrison · Lotten Ragnarsson · Sarah O. Cook · Joseph A. Rothnagel · Ernst Wolvetang · Bahaa Al-mhanawi · Mohammed R. Shaker · Thomas Robertson · Peter R. Dodd · Peter G. Noakes

  Frontiers in Synaptic Neuroscience

  doi 10.3389/fnsyn.2026.1760254

• Original Research

  Published 12 May 2026

  Identifying microbial biomarkers of neurodegeneration: a comparative study in Alzheimer’s and Parkinson’s disease

  Simon De Jaegher · David Pinzauti · Maria D’Aguanno · Erika Parkinson · James Schofield · Fabio Strazzeri · Paul Skipp · Rebekah Penrice-Randal · Amy Kunicki · Beth McCausland · Christopher Kipps · Jay Amin · Manuele Biazzo

  Frontiers in Microbiomes

  doi 10.3389/frmbi.2026.1831956

• Original Research

  Published 1 May 2026

  Stereological evaluation of the neuroprotective effects of curcumin on the spinal cord in a streptozotocin-induced diabetic rat model

  Burcu Delibaş · Ayşe İkinci Keleş · Arife Ahsen Kaplan · Berk Kocaman · Gamze Altun · Kıymet Kübra Tüfekci · Abit Aktaş · Süleyman Kaplan

  Frontiers in Neuroanatomy

  doi 10.3389/fnana.2026.1822774

• Original Research

  Published 28 April 2026

  NIH Stroke Scale and age predict early post-stroke cognitive impairment

  Faddi Saleh Velez · Cameron D. Owens · Jennifer Hotson · Andrea Loggini · Ana Luyza Oliveira Santos · Demian Rudyk · Daniela Mercado Pena · Melba Zuniga-Gutierrez · Maria Cedeno-Bruzual · Laura Boada Robayo · Cheyenne Gutierrez · Kate Singleton · Zyanna Stuart · Evgeny Sidorov · Andriy Yabluchanskiy · Camila Bonin Pinto

  Frontiers in Stroke

  doi 10.3389/fstro.2026.1762758