Original ResearchPublished 12 October 2026Camk2d upregulation is associated with postoperative cognitive dysfunction in aged rats: pharmacological inhibition of CaMKII attenuates hippocampal neuroinflammation and neuronal apoptosisKaihua Wei · Shiwen Fan · Yujia Zhao · Xiaobin Cai · Xinlei Qin · Jingwen Zhai · Liping XieFrontiers in Aging Neurosciencedoi 10.3389/fnagi.2026.1975677
ReviewPublished 12 October 2026Immunometabolic crosstalk between dysfunctional adipose tissue and the brain: implications for postoperative cognitive dysfunction in obesityYa-Jiao Hu · Juan Ni · Jin-Xi ZhangFrontiers in Immunologydoi 10.3389/fimmu.2026.1965479
Systematic ReviewPublished 1 October 2026Circulating and cerebrospinal fluid soluble TREM2 levels and risk of perioperative neurocognitive disorders in surgical patients: a systematic review and meta-analysisHaotian Wu · Yujie Wang · Zhifeng Gao · Huan ZhangFrontiers in Aging Neurosciencedoi 10.3389/fnagi.2026.1899745
Original ResearchPublished 7 September 2026Association between preoperative cognitive impairment and perioperative neurocognitive disorders within 30 days after surgery in elderly patients: a secondary exploratory retrospective analysisKeke Song · Ping He · Xiaoqi Zhao · Rongsheng Zhou · Yaomin Zhu · Xiaofei Liu · Xin ZhangFrontiers in Agingdoi 10.3389/fragi.2026.1835897
ReviewPublished 2 September 2026Neuroinflammation in postoperative cognitive dysfunction: the multi-target potential of esketamine in modulating microglial responses and synaptic integrityHao-Tian Li · Guang-Yong Lin · Wen-Tao Xing · Yu Liu · Chuan-Xiang ZhangFrontiers in Molecular Neurosciencedoi 10.3389/fnmol.2026.1868647
Original ResearchPublished 26 May 2026A novel 1-channel EEG marker may associate with perioperative cognitive changeDana Baron Shahaf · Gil Bolotin · Oved Cohen · Mahli Raad · Raphael Derman · Goded ShahafFrontiers in Systems Neurosciencedoi 10.3389/fnsys.2026.1688834
EditorialPublished 18 May 2026Editorial: Neuroinflammation in postoperative cognitive dysfunction and related disordersYing Li · Jie Xiao · Mingqin Zhu · Pei ShangFrontiers in Anesthesiologydoi 10.3389/fanes.2026.1807728