Original ResearchPublished 28 September 2026Two decades of prescription opioid-related cardiovascular safety signals: a FAERS-based pharmacovigilance study using machine learningLi Ma · Johnna Berryhill · John Ihrie · Ru Chen · Beverly Lyn-Cook · Paul Rogers · Weigong Ge · Ningning Wu · Huixiao Hong · Weida Tong · Wen ZouFrontiers in Drug Safety and Regulationdoi 10.3389/fdsfr.2026.1898403