Original ResearchPublished 12 October 2026Beyond binary: a novel anatomical-geographical-biological framework for perineural invasion risk stratification in oral squamous cell carcinoma – a proof-of-concept studyShanthi Velusamy · Prajwal Dange · Karthik N. Rao · Teertha Shetty · Nethra R. · Rekha V. Kumar · Karthik S. Rishi · Aruna Korlimarla · Srinath B.S. · Sreeram M.P.Frontiers in Oncologydoi 10.3389/fonc.2026.1897905
Original ResearchPublished 12 October 2026Deep-learning analysis suggests a facial image signal associated with low muscle mass in a clinical cohort enriched for chronic liver disease: a proof-of-concept studyThomas Fuchs · Akhila Abdulnazar · Lavra Rebol · Peter Fickert · Thomas Gremsl · Vanessa StadlbauerFrontiers in Cell and Developmental Biologydoi 10.3389/fcell.2026.1964880
Original ResearchPublished 9 October 2026Processing poor quality ram semen by colloid centrifugation prior to freezing: a proof-of-concept studyJane M. MorrellFrontiers in Veterinary Sciencedoi 10.3389/fvets.2026.1946483
Original ResearchPublished 7 October 2026Simultaneous hyperkinetic movement disorders phenotyping: a cross-cohort pediatric transfer study using routine videos, markerless pose estimation and a tabular foundation modelLaura Cif · Diane Demailly · Zohra Souei · Muhammad Mushhood Ur Rehman · Juan Dario Ortigoza-Escobar · Mayté Castro-Jiménez · Cécile A. Hubsch · Sophie Huby · Morgan Dornadic · Gun-Marie Hariz · Eduardo M. Moraud · Jocelyne Bloch · Gabriella A. Horvàth · Xavier VasquesFrontiers in Neurologydoi 10.3389/fneur.2026.1904458
Original ResearchPublished 28 September 2026Activity-based first estrus detection in grazing heifers and first-lactation dairy cows for use as novel fertility phenotypes at scaleSimon J. R. Woodward · Daniel P. Garrick · Nicole M. Steele · Melissa A. Stephen · Claire V. C. Phyn · Susanne Meier · Chris R. BurkeFrontiers in Animal Sciencedoi 10.3389/fanim.2026.1916553
Brief Research ReportPublished 15 September 2026Transformation of 6:2 fluorotelomer sulfonic acid in laccase-mediator systemsUmar Munir · Yifei Wang · Xi Zhu · Yuqing Ji · Mussie Y. Habteselassie · Andrea Squartini · Qingguo HuangFrontiers in Environmental Engineeringdoi 10.3389/fenve.2026.1948940
Original ResearchPublished 15 September 2026Virtual health coach acceptance in point-of-care settings among community-dwelling older adults: a mixed-method proof-of-concept studyMichael Joseph Dino · Jerald Sayat · Chloe Margalaux Villafuerte · Joseph Carlo Vital · Justin Pimentel · Dave Carlo Palicpic · Gretchen Masayon · Megha Parikh · Jian Zou · Sergi Garcia-Retortillo · Ladda Thiamwong · Mona ShattellFrontiers in Virtual Realitydoi 10.3389/frvir.2026.1918500
Brief Research ReportPublished 14 September 2026Developing a spherical video-based virtual reality program to facilitate embodiment: a proof-of-concept studyNancy A. Baker · Alexandro Guerrero · Robert R. EdwardsFrontiers in Virtual Realitydoi 10.3389/frvir.2026.1878621
Original ResearchPublished 3 September 2026Human-in-the-loop proof of concept for lunar teleoperation: performance, workload, and neuro-physiological insights from the LUNA Analog FacilityElena Lopez-Contreras · Lua Delaunoit · Axel Coulon · Laure Boyer · Alexis Paillet · Raphaëlle N. Roy · Aidan Cowley · Vsevolod PeysakhovichFrontiers in Space Technologiesdoi 10.3389/frspt.2026.1920649
Brief Research ReportPublished 19 August 2026High-titer human packaging cells producing γ-retroviral vectors pseudotyped with engineered baboon endogenous retrovirus (BaEV) envelope proteinsAngelina Hallik · Mona Pißarreck · Mats Jürgen Grummel · Yasemin van Heuvel · Jörn StitzFrontiers in Molecular Medicinedoi 10.3389/fmmed.2026.1888550
Original ResearchPublished 19 August 2026Graph Neural Networks with dilated convolutions for geomagnetic field forecasting: a single-station topological approachBryan Tipán · Ericson López · William Carvajal · Leonel GuamánFrontiers in Astronomy and Space Sciencesdoi 10.3389/fspas.2026.1854971
Original ResearchPublished 12 August 2026Personalised route guidance to reduce air pollution exposure during active commuting: a proof-of-concept study using graph-based network analysis in Leicester, UKJames A. Donaldson · Joshua Vande Hey · Samuel Cai · Anna Hansell · Jamie O’Driscoll · Rikesh Panchal · Sarah Johnson · Andre NgFrontiers in Sustainable Citiesdoi 10.3389/frsc.2026.1869860
Original ResearchPublished 11 August 2026Ultrasound echo envelope statistics to differentiate glioblastoma multiforme from normal brain tissue ex vivo: a proof-of-concept studyJagruti M. Patil · Mihir Agarwal · Shilpa Rao · Vikas Vazhayil · Hardik J. Pandya · Anita Mahadevan · Himanshu Shekhar · Karla P. Mercado-ShekharFrontiers in Acousticsdoi 10.3389/facou.2026.1882624
Original ResearchPublished 6 July 2026Plastic surface-immobilized primers for integrated DNA capture and purification in simplified molecular diagnostics - a proof-of-concept studyTochukwu Dubem AnyadubaFrontiers in Lab on a Chip Technologiesdoi 10.3389/frlct.2026.1867993
Original ResearchPublished 3 July 2026Potential of Image2Image translation in reducing AI bias attributed to differences in CT reconstruction methods: proof-of-concept study on a paired datasetFeifei Li · Liliana Lourenco Caldeira · Astha Jaiswal · Nils Große Hokamp · Oya Beyan · Ekaterina KutafinaFrontiers in Radiologydoi 10.3389/fradi.2026.1875867
Original ResearchPublished 25 June 2026Using interpretable decision trees to explore TB-HIV integration under data constraints: a proof-of-concept analysisNtandazo Dlatu · Lindiwe Modest Faye · Mojisola Clara Hosu · Teke ApalataFrontiers in Tuberculosisdoi 10.3389/ftubr.2026.1853414
Original ResearchPublished 10 April 2026Immunometabolic reprogramming of Mycobacterium tuberculosis -responsive memory CD4 + T cell subsets is linked to long-term protective immunityVaishnavi Kaipilyawar · Samantha Leong · Arianne Lovey · Lorenzzo L. Stringari · Reynaldo Dietze · Jerrold J. Ellner · Rodrigo Ribeiro-Rodrigues · Padmini SalgameFrontiers in Tuberculosisdoi 10.3389/ftubr.2026.1783887
Brief Research ReportPublished 27 March 2026Toward efficient surveillance: a proof-of-concept comparison of methods for detecting DNA and RNA viruses in wastewaterMarek Samec · Ivana Baranová · Renata Péčová · Martin Péč · Elena Nováková · Iryna Samec · Vincent LučanskýFrontiers in Virologydoi 10.3389/fviro.2026.1733412
Analytical SciencePublished 19 November 2024Forensic identification and differentiation of some protected timber species using ATR-FTIR spectroscopy and chemometricsArti Yadav · Sweety Sharma · Vaibhav Singh · Manish Kapoor · Rajinder SinghFrontiers in Analytical Sciencedoi 10.3389/frans.2024.1508509
Drug DeliveryPublished 16 September 2024Electrospun patches to deliver combination drug therapy for fungal infectionsKarolina Dziemidowicz · Mark Meszarik · Jacopo Piovesan · Mazna A. Almatroudi · Gareth R. Williams · Sudaxshina MurdanFrontiers in Drug Deliverydoi 10.3389/fddev.2024.1458009