Original ResearchPublished 12 January 2026Development of a comprehensive approach for the characterization of polar plant decoctions by orthogonal LC-MS reversed phase, HILIC, and NMR metabolite profiling: the case of Combretum micranthumLisa Vuadens · Robin Huber · Laurence Marcourt · Luis-Manuel Quiros-Guerrero · Olivier Auguste Kirchhoffer · Arnaud Gaudry · Renata Campos Nogueira · Elhadji Assane Diop · Sidi Mohamed Seck · Jean-Luc Wolfender · Emerson Ferreira QueirozFrontiers in Natural Productsdoi 10.3389/fntpr.2025.1717575