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Every article on Frontiers is peer reviewed, permanently archived and free to read.

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Brief Research Report
Published 15 September 2026
R2Tg retrotransposon mediated targeted integration of exogenous genes into the 28S rDNA locus in mammalian cell lines for PKU gene therapy
Xiuyuan Wang · Ziqi Wen · Rongjun Xu · Wenjing Shi · Yiling Long · Xingri Zhan · Rui Su · Jia Fei · Yumin Li
Frontiers in Genome Editing
doi 10.3389/fgeed.2026.1893815
Review
Published 4 September 2026
Rewriting the genome: harnessing R2 retrotransposons for precise DNA insertion
Liangzheng Fu · Yachao Wu · Xiaohua Jin · Xu Ma
Frontiers in Genome Editing
doi 10.3389/fgeed.2026.1789016