Original ResearchPublished 21 May 2026Tolazoline, an alpha-adrenergic antagonist, may also block xylazine at off-target sites as inferred from molecular dockingGiuseppe Floresta · Vincenzo Patamia · Alberto Granzotto · Davide Arillotta · Gabriele Duccio Papanti · Amira Guirguis · John M. Corkery · Giovanni Martinotti · Stefano L. Sensi · Fabrizio SchifanoFrontiers in Chemical Biologydoi 10.3389/fchbi.2026.1806456