Review
Published
Strategic roadmap for FAIR-compliant transcriptomic workflows: from technical challenges to bioinformatics democratization
Verónica Jiménez Jacinto · Leticia Vega-Alvarado
Frontiers in Bioinformatics
doi 10.3389/fbinf.2026.1882808
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Showing 176 articles
Original Research
Published
The arginine repressor ArgR controls virulence factors of adherent-invasive Escherichia coli strains
Queralt Bonet-Rossinyol · Margarita Martinez-Medina · Llorenç Fernández-Coll
Frontiers in Cellular and Infection Microbiology
doi 10.3389/fcimb.2026.1941024
Original Research
Published
Explainable machine learning integrating CT-derived intratumoral heterogeneity for histological subtype prediction in pure ground-glass lung adenocarcinoma: multicenter validation and transcriptomic characterization
Ying Deng · Jiajun Liu · Dinghua Li · Bingyi Zhang · Bin Xiang · Wanyin Qi · Sanhong Zhang
Frontiers in Molecular Biosciences
doi 10.3389/fmolb.2026.1958127
Original Research
Published
Comparative transcriptomic analysis reveals the protective mechanism of ferulic acid against lipopolysaccharide-induced ferroptosis in IPEC-J2 cells
Jiayu Chen · Hongchao Li · Yaxuan Niu · Tao Guo · Xiangyu Wang · Yue Zhang · Wenwen Wang · Yuanqing Xu · Yuan Wang · Mingxing Chu
Frontiers in Veterinary Science
doi 10.3389/fvets.2026.1950560
Original Research
Published
Integrated metabolomic and single-cell analyses reveal crotonylation-related epithelial remodeling and SDC4 dysregulation in adenomyosis
Jiaxi Wang · Yue Li · Hongyu Zhang · Yiling Zhao · Wei Fan · Wenhu Xin · Chunhua Qiang · Tiansheng Qin
Frontiers in Nutrition
doi 10.3389/fnut.2026.1917718
Review
Published
From peri-implant distance ranges to spatial niches: a resolution-aware analytical framework for the intracortical microelectrode–brain interface
Miaozhe Huo · Zhengyang Xue · Yifei Sheng · Shiying Li
Frontiers in Materials
doi 10.3389/fmats.2026.1969087
Review
Published
Multi-omics insights into immune dysregulation and candidate biological programs in kawasaki disease: toward precision immunomodulation
Yun Han · Jiaying Liu · Chengxu Song · Li Fu · Yu Gu · Yu Zeng · Zhenzhuang Zou
Frontiers in Pediatrics
doi 10.3389/fped.2026.1960681
Review
Published
Gut microbiota, microbial metabolites, and mucosal barrier dysfunction in benign anorectal disorders and ulcerative colitis: shared mechanisms, clinical links, and precision interventions
Hexue Yuan · Maofang Zhao · Yunfen Wang · Chen Shen · Delong Liu · Chunxiao Wang · Jian Liu
Frontiers in Medicine
doi 10.3389/fmed.2026.1979206
Original Research
Published
Diffusible signals from Azospirillum brasilense promote rice growth and induce distinct gene expression changes in plant roots
Samuel Hoggard · Matthew Calhoun · Anna Bommes · Yasir Rahmatallah · Dylan Neuhaus · Galina Glazko · Arijit Mukherjee
Frontiers in Plant Science
doi 10.3389/fpls.2026.1911178
Review
Published
Functional single-cell omics in gynecological cancers immunotherapy: from heterogeneity dissection to clinical translation
Dong-mei Li · Kai-ge Pei · Bo-wen Yang · Ming-rong Qie · Jin-feng Xu · Lan Zhong · Liang Song
Frontiers in Immunology
doi 10.3389/fimmu.2026.1981010
Original Research
Published
Genome-wide analysis of the GATA gene family in Castanea mollissima reveals key regulators involved in salt stress response
Xiangyu Wang · Xili Liu · Jun Liu · Le Niu · Huoqiang Quan · Tong Zhang · Qinuo Li · Guoyun Zhang · Liyang Yu
Frontiers in Plant Science
doi 10.3389/fpls.2026.1907055
Original Research
Published
Integrative multi-omics reveal the impact of different light spectra on lateral branching and growth of medicinal plant Artemisia argyi
Ahad Mehmood · Zhao Yipeng · Jiali Song · Zhenchao Yang · Yongjun Wu
Frontiers in Plant Science
doi 10.3389/fpls.2026.1871654
Original Research
Published
Integrative population genetics and multi-omics reveal IL15RA as a shared pathogenic hub in rheumatoid arthritis-related heart failure
Qishun Geng · Chaoying Wen · Meijia Yang · Yuhan Zhou · Meng Yang · Qishun Geng · Jie Zhao
Frontiers in Immunology
doi 10.3389/fimmu.2026.1956897
Original Research
Published
Comparative transcriptomics of outbreak-associated Salmonella Heidelberg, Typhimurium, and monophasic Typhimurium reveals differential expression of stress tolerance, virulence, and biofilm-associated genes
Chelsey A. Patch · Andrea J. Etter
Frontiers in Microbiology
doi 10.3389/fmicb.2026.1895105
Original Research
Published
Sub-lethal dose exposure of cyflufenamid, flutianil, quinoxyfen, trifloxystrobin and metrafenone effects on conidial germination and gene expression in the grape powdery mildew pathogen
Nancy Sharma · Mohit Mahey · Rachel P. Naegele · Timothy D. Miles
Frontiers in Microbiology
doi 10.3389/fmicb.2026.1944688
Mini Review
Published
Spatial heterogeneity in glioblastoma: linking single-cell and spatial multi-omics to vaccine immunotherapy
Juan Yuan · Yong Liu
Frontiers in Immunology
doi 10.3389/fimmu.2026.1921816
Original Research
Published
Clinical-scale manufacturing of CD137+ enriched tumor-reactive T cells for glioblastoma in the CliniMACS Prodigy
Arina Riabinska · Elvira Criado-Moronati · Emre Balta · Denis Frison · Cristina Berganza-Irusqueta · Tümay Telatar · Donata Maciaczyk · Johanna Engeln · Laura Fischer · Marieke Domdey · Imran Siddiqui · Velita Miranda · Teresa Schmidt · Sied Kebir · Yahya Ahmadipour · Martin Glas · Ulrich Herrlinger · Matthias Schneider · Anna-Laura Potthoff · Marcus Czabanka · Thomas Broggini · Sofia Stenqvist · Lisa M. Nilsson · Jonas A. Nilsson · Martina Ott · Andrzej Dzionek · Ian R. Hardy
Frontiers in Immunology
doi 10.3389/fimmu.2026.1866645
Original Research
Published
Integrative single-cell and bulk transcriptomic analysis identifies monocyte/macrophage senescence-associated candidate genes in pulmonary arterial hypertension
Xiaojun Chen · Weibin Wu · Yilong Liu · Guili Lian · Qingquan Liu
Frontiers in Immunology
doi 10.3389/fimmu.2026.1938985
Original Research
Published
Spatial analysis of placentae during congenital cytomegalovirus infection suggests distinct cellular profiles in immune and trophoblast cells: an exploratory study
Elise Sintim-Aboagye · Huy Quang Quach · Indrani Mukherjee · Will Sherman · Katelyn T. Nguyen · Neil Ferland · Sheila Farnan · Kamila Otrubova · Namisha Verma · Dawn Littlefield · Sohan Punia · Erica Johnson · Mark Blackstad · Mark R. Schleiss · Andrew P. Norgan · Clive M. Gray · Elizabeth Ann L. Enninga · Rana Chakraborty
Frontiers in Immunology
doi 10.3389/fimmu.2026.1885923
Original Research
Published
Taxifolin alleviates podocyte injury and macrophage chemotaxis associated with diabetic nephropathy by directly targeting RBP1 identified via multi-omics and machine learning
Zi-Xuan Wang · Wen-Xuan Wang · Qiong-Dan Liang · Ling-Dong Kong
Frontiers in Pharmacology
doi 10.3389/fphar.2026.1933167
Original Research
Published
Selective inhibition of aldosterone production modulates human adrenocortical (HAC15) cell fate
Kha Chin Long · Amnani Aminuddin · Najiah Ajlaa Ayub · Geok Chin Tan · A. Rahman A. Jamal · Nor Azian Abdul Murad · Nor Adzimah Johdi · Celso E. Gomez-Sanchez · Norlela Sukor · Morris J. Brown · Elena A. Azizan
Frontiers in Endocrinology
doi 10.3389/fendo.2026.1872432
Original Research
Published
Study on the promoting effect of microplastic exposure on prostate cancer migration and invasion based on network toxicology and single-cell sequencing technology
Haiyang Jiang · Ying Bi · Longguo Dai · Yong Zhu · Ruikang Zhang · Chen Hu · Hong Yang · Jun Li · Chongjian Zhang · Yu Bai · Ruiqian Li
Frontiers in Oncology
doi 10.3389/fonc.2026.1973812
Original Research
Published
Cross-species transcriptomic plasticity and root architectural adaptations in Brachypodium ( Brachypodium distachyon ) and barley ( Hordeum vulgare ) genotypes under different ammonium and nitrate availability
Hamid Rouina · Dilkaran Singh · Christopher Arlt · Amy Marshall-Colon · Benjamin Stich
Frontiers in Plant Science
doi 10.3389/fpls.2026.1916213
Original Research
Published
Distinct temporal trajectories of EPAS1 mRNA expression during moderate-altitude training in Han and Tibetan endurance athletes
Qing-Qing Su · Hai-Lin Ma · Yan-Lin Sun · Fu-Hai Ma · Yan-Chang Shen · Jian Wang · Xiao-Wei Ma · Jiang-Long Zhang · Yang Zhang · Erik R. Swenson
Frontiers in Cell and Developmental Biology
doi 10.3389/fcell.2026.1973797
Original Research
Published
Histopathology-guided spatial transcriptomic analysis identifies an ECM-associated stromal pattern in lacrimal gland adenoid cystic carcinoma with complementary proteomic and functional analyses
Rong Luan · Difei Zuo · Yeqing Wang · Meixia Jiang · Xun Liu · Limin Zhu · Tingting Lin
Frontiers in Pharmacology
doi 10.3389/fphar.2026.1949721
Original Research
Published
The role of ferro-aging genes in periodontitis: novel insights based on bioinformatics analysis
Poyi Chu · Danhua Wu · Jianwen Deng · XuFeng Chen
Frontiers in Cellular and Infection Microbiology
doi 10.3389/fcimb.2026.1875267
Review
Published
Molecular mechanisms regulating differential expression of individual miRNAs within polycistronic clusters
Diana Maltseva · Alexander Tonevitsky
Frontiers in Molecular Biosciences
doi 10.3389/fmolb.2026.1913118
Correction
Published
Correction: Transcriptomic insights into the molecular regulatory mechanism of staminody in Chinese narcissus ( Narcissus tazetta subsp. chinensis )
Pengda Zhao · Yuting Yang · Na Zhang · Keke Fan · Yanting Chang · Baokun Yan · Hanchen Tian · Zehui Jiang · Yanjun Ma · Tao Hu
Frontiers in Plant Science
doi 10.3389/fpls.2026.2016040
Original Research
Published
Thioredoxins as hormone-responsive redox regulators in wheat: transcriptomic and structural insights
Mohammed Hashim Bouzenita · Rana Adnan Tahir · Mengjie Fan · Aisha Shabib Estanbooli · Kamel Chibani
Frontiers in Plant Science
doi 10.3389/fpls.2026.1911123
Original Research
Published
Integrated physiological and transcriptomic analyses reveal cell wall remodeling underlying firmness retention in a firm-fruited blueberry genotype
Bowei Wang · Chenxin Yu · Yibo Ma · Xiaoxuan Tang · Yadong Li · Haiyue Sun
Frontiers in Plant Science
doi 10.3389/fpls.2026.1962192
Original Research
Published
Integrative phenotypic and transcriptomic validation of an alveolar-like macrophage model reveals early host–pathogen dynamics during Aspergillus fumigatus infection
Jeany Söhnlein · Sascha Schäuble · Juan Prada Salcedo · Zahraa Abboud · Dalia Sheta · Kerstin Hünniger-Ast · Michelle Seif · Hermann Einsele · Thomas Dandekar · Gianni Panagiotou · Andreas Beilhack · Juergen Loeffler
Frontiers in Microbiology
doi 10.3389/fmicb.2026.1922948
Original Research
Published
Pathway-level analysis suggests a maintenance-oriented transcriptional response of the ammonia-oxidizing bacterium Nitrosospira sp. NT to acidic pH
Yuxiang Song · Zhongjun Jia
Frontiers in Microbiology
doi 10.3389/fmicb.2026.1957381
Original Research
Published
A light-responsive engineered probiotic system to alleviate anxiety via gut-brain axis
Yuling Chang · Zhaofang Hang · Yuhan Zhang · Yuhao Zhu · Xingang Li · Xuejun Wang · Di Zhang
Frontiers in Bioengineering and Biotechnology
doi 10.3389/fbioe.2026.1864003
Original Research
Published
A zebrafish model of NEXMIF-related encephalopathy identified drivers of hyperlocomotion and provides a scalable platform for drug discovery
Beatriz Bernal-Bermúdez · Francisco J. Martínez-Morcillo · Inmaculada Fuentes-Martínez · Alicia Martínez-López · María L. Cayuela · Victoriano Mulero · Diana García-Moreno
Frontiers in Cell and Developmental Biology
doi 10.3389/fcell.2026.1899363
Original Research
Published
Amomum tsao-ko volatile oil alleviates renal fibrosis in 5/6 nephrectomy rats through TGF- β 1/SMAD3 and PI3K/AKT signaling pathways
Huanyue Cui · Meiru Shi · Qing Xu · Shangwen Zhou · Xin Li · Hangyu Wang · Dahong Yao · Ke Zhang · Pinghua Sun · Jinhui Wang
Frontiers in Pharmacology
doi 10.3389/fphar.2026.1819932
Review
Published
Artificial intelligence - driven toxicogenomics for predictive environmental and pharmaceutical safety
Mohammed Monirul Islam · Sibghatullah Muhammad Ali Sangi · Girish Meravanige · Sreeharsha Nagaraja · Muhammad Shahzad Chohan · Md Khalid Anwer · Ashesh Gurung
Frontiers in Genetics
doi 10.3389/fgene.2026.1858338
Original Research
Published
Identification of microglia-associated hub genes and a CX3CR1/P2RY12 two-gene diagnostic model for cross-subtype epilepsy-associated cortical malformations: integrated transcriptomic analysis with external validation
Hongliang Zeng · Bin Li
Frontiers in Neuroscience
doi 10.3389/fnins.2026.1954412
Review
Published
The role of personalised medicine in treating high-risk neuroblastoma in paediatric patients
Daniele Ammeti · Debora Curci · Martina Franzin · Marco Rabusin · Melania Eva Zanchetta · Antonella Fabretto
Oncology Reviews
doi 10.3389/or.2026.1850627
Original Research
Published
Astrocyte maturation creates a stage-specific niche that instructs hippocampal neurogenesis
Evangelia Masouti · Lucía Casares-Crespo · Andreas Sagner · Arne Gessner · Martin F. Fromm · Helena Mira · Ruth Beckervordersandforth
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1966983
Original Research
Published
Integrating transcriptomic analysis and experimental validation unravels autophagy- and lactylation-related gene signatures in acute myocardial infarction
Jun Peng · Li Chen · Lizhen Liu · Xiangdong Xu · Huiwen Song
Frontiers in Cardiovascular Medicine
doi 10.3389/fcvm.2026.1814910
Brief Research Report
Published
Equine (Equus caballus) primary post-natal brain-derived cells: immortalization and preliminary reprogramming attempts to induced pluripotent stem cells
Antonella Molinari · Camilla Lucca · Stefania Vogiatzis · Valentina Moccia · Massimiliano Babbucci · Luca Peruzza · Enrico Negrisolo · Marta Trevisan · Luisa Barzon · Cinzia Centelleghe · Sandro Mazzariol · Valentina Elena Giuditta Zappulli
Frontiers in Veterinary Science
doi 10.3389/fvets.2026.1931938
Review
Published
Balloon cells in type II focal cortical dysplasia: developmental origins, molecular signatures, and epileptogenic mechanisms
Yan Gao · Xinna Ji · Shuo Feng · Yanyan Gao · Lingxue Li · Bing Wang · Xue Zhang · Qian Chen
Frontiers in Cell and Developmental Biology
doi 10.3389/fcell.2026.1963535
Original Research
Published
MGCF-Net: a multi-view granular-ball contrastive fusion network for spatial transcriptomics clustering
Li Zhu · Haiyao Dong · Yuji Zhang · Yong Zhang · Xinyi Huang · Huishan Wang
Frontiers in Physiology
doi 10.3389/fphys.2026.1967219
Brief Research Report
Published
Transcriptomic insights into loperamide-induced gastric dysmotility: RNA-seq analysis of a mouse model
Chunggeon Lee · Seung-Ju Hwang · Young-Su Yang · Bokyung Kim · Dong-Seon Kim · Daeui Park · Chang-Woo Song · Chang-Gue Son
Frontiers in Physiology
doi 10.3389/fphys.2026.1924065
Original Research
Published
Reference-signature projection framework for exercise transcriptomic directionality based on the IAV-DI reference axis
Anli Zhou · Min Zhang · Cheng Zhang · Jianjun Guo · Min Zhang · Yan Zhang
Frontiers in Physiology
doi 10.3389/fphys.2026.1943015
Original Research
Published
Genome-wide analysis of cork oak NLRs reveals RNL-associated duplications and immune receptor candidates associated with biotic and abiotic stress response
L. M. Gonçalves · M. M. Oliveira · P. M. Barros
Frontiers in Genetics
doi 10.3389/fgene.2026.1894037
Original Research
Published
Multi-cohort meta-analysis, single-cell and Mendelian randomization analyses with experimental validation identify RHBDF2 as a shared mediator of ulcerative colitis and blood–brain barrier disruption
Jiongjiong Cheng · Aman Xu
Frontiers in Synaptic Neuroscience
doi 10.3389/fnsyn.2026.1970578
Original Research
Published
Integrated transcriptomic and proteomic profiling reveals C3-associated hippocampal neuroimmune remodeling in sodium bicarbonate-treated sepsis-associated encephalopathy
Housheng Deng · Hua Ling · Lie Liu · Qiuli He · Hao Wang · Zhiming Zhang
Frontiers in Neuroscience
doi 10.3389/fnins.2026.1954272