Review
Published
Strategic roadmap for FAIR-compliant transcriptomic workflows: from technical challenges to bioinformatics democratization
Verónica Jiménez Jacinto · Leticia Vega-Alvarado
Frontiers in Bioinformatics
doi 10.3389/fbinf.2026.1882808
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Every article on Frontiers is peer reviewed, permanently archived and free to read.
Showing 76 articles
Original Research
Published
The arginine repressor ArgR controls virulence factors of adherent-invasive Escherichia coli strains
Queralt Bonet-Rossinyol · Margarita Martinez-Medina · Llorenç Fernández-Coll
Frontiers in Cellular and Infection Microbiology
doi 10.3389/fcimb.2026.1941024
Original Research
Published
Explainable machine learning integrating CT-derived intratumoral heterogeneity for histological subtype prediction in pure ground-glass lung adenocarcinoma: multicenter validation and transcriptomic characterization
Ying Deng · Jiajun Liu · Dinghua Li · Bingyi Zhang · Bin Xiang · Wanyin Qi · Sanhong Zhang
Frontiers in Molecular Biosciences
doi 10.3389/fmolb.2026.1958127
Review
Published
From peri-implant distance ranges to spatial niches: a resolution-aware analytical framework for the intracortical microelectrode–brain interface
Miaozhe Huo · Zhengyang Xue · Yifei Sheng · Shiying Li
Frontiers in Materials
doi 10.3389/fmats.2026.1969087
Review
Published
Multi-omics insights into immune dysregulation and candidate biological programs in kawasaki disease: toward precision immunomodulation
Yun Han · Jiaying Liu · Chengxu Song · Li Fu · Yu Gu · Yu Zeng · Zhenzhuang Zou
Frontiers in Pediatrics
doi 10.3389/fped.2026.1960681
Review
Published
Gut microbiota, microbial metabolites, and mucosal barrier dysfunction in benign anorectal disorders and ulcerative colitis: shared mechanisms, clinical links, and precision interventions
Hexue Yuan · Maofang Zhao · Yunfen Wang · Chen Shen · Delong Liu · Chunxiao Wang · Jian Liu
Frontiers in Medicine
doi 10.3389/fmed.2026.1979206
Review
Published
Functional single-cell omics in gynecological cancers immunotherapy: from heterogeneity dissection to clinical translation
Dong-mei Li · Kai-ge Pei · Bo-wen Yang · Ming-rong Qie · Jin-feng Xu · Lan Zhong · Liang Song
Frontiers in Immunology
doi 10.3389/fimmu.2026.1981010
Original Research
Published
Integrative population genetics and multi-omics reveal IL15RA as a shared pathogenic hub in rheumatoid arthritis-related heart failure
Qishun Geng · Chaoying Wen · Meijia Yang · Yuhan Zhou · Meng Yang · Qishun Geng · Jie Zhao
Frontiers in Immunology
doi 10.3389/fimmu.2026.1956897
Original Research
Published
Comparative transcriptomics of outbreak-associated Salmonella Heidelberg, Typhimurium, and monophasic Typhimurium reveals differential expression of stress tolerance, virulence, and biofilm-associated genes
Chelsey A. Patch · Andrea J. Etter
Frontiers in Microbiology
doi 10.3389/fmicb.2026.1895105
Original Research
Published
Sub-lethal dose exposure of cyflufenamid, flutianil, quinoxyfen, trifloxystrobin and metrafenone effects on conidial germination and gene expression in the grape powdery mildew pathogen
Nancy Sharma · Mohit Mahey · Rachel P. Naegele · Timothy D. Miles
Frontiers in Microbiology
doi 10.3389/fmicb.2026.1944688
Mini Review
Published
Spatial heterogeneity in glioblastoma: linking single-cell and spatial multi-omics to vaccine immunotherapy
Juan Yuan · Yong Liu
Frontiers in Immunology
doi 10.3389/fimmu.2026.1921816
Original Research
Published
Taxifolin alleviates podocyte injury and macrophage chemotaxis associated with diabetic nephropathy by directly targeting RBP1 identified via multi-omics and machine learning
Zi-Xuan Wang · Wen-Xuan Wang · Qiong-Dan Liang · Ling-Dong Kong
Frontiers in Pharmacology
doi 10.3389/fphar.2026.1933167
Original Research
Published
Histopathology-guided spatial transcriptomic analysis identifies an ECM-associated stromal pattern in lacrimal gland adenoid cystic carcinoma with complementary proteomic and functional analyses
Rong Luan · Difei Zuo · Yeqing Wang · Meixia Jiang · Xun Liu · Limin Zhu · Tingting Lin
Frontiers in Pharmacology
doi 10.3389/fphar.2026.1949721
Original Research
Published
Pathway-level analysis suggests a maintenance-oriented transcriptional response of the ammonia-oxidizing bacterium Nitrosospira sp. NT to acidic pH
Yuxiang Song · Zhongjun Jia
Frontiers in Microbiology
doi 10.3389/fmicb.2026.1957381
Original Research
Published
Amomum tsao-ko volatile oil alleviates renal fibrosis in 5/6 nephrectomy rats through TGF- β 1/SMAD3 and PI3K/AKT signaling pathways
Huanyue Cui · Meiru Shi · Qing Xu · Shangwen Zhou · Xin Li · Hangyu Wang · Dahong Yao · Ke Zhang · Pinghua Sun · Jinhui Wang
Frontiers in Pharmacology
doi 10.3389/fphar.2026.1819932
Review
Published
The role of personalised medicine in treating high-risk neuroblastoma in paediatric patients
Daniele Ammeti · Debora Curci · Martina Franzin · Marco Rabusin · Melania Eva Zanchetta · Antonella Fabretto
Oncology Reviews
doi 10.3389/or.2026.1850627
Original Research
Published
MGCF-Net: a multi-view granular-ball contrastive fusion network for spatial transcriptomics clustering
Li Zhu · Haiyao Dong · Yuji Zhang · Yong Zhang · Xinyi Huang · Huishan Wang
Frontiers in Physiology
doi 10.3389/fphys.2026.1967219
Original Research
Published
Reference-signature projection framework for exercise transcriptomic directionality based on the IAV-DI reference axis
Anli Zhou · Min Zhang · Cheng Zhang · Jianjun Guo · Min Zhang · Yan Zhang
Frontiers in Physiology
doi 10.3389/fphys.2026.1943015
Original Research
Published
Transcriptomic analysis identifies candidate molecular mechanisms underlying SCF+G-CSF-reduced neuropathology in aged APP/PS1 mice
Afua Addo · Bin Li · Sasidhar Murikinati · Robert Gardner · Li-Ru Zhao
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1705436
Editorial
Published
Editorial: Multi-omics insights into exercise-induced molecular adaptations
Lixian He · Haibo Wang · Qingzheng Kang · Liang Zhang
Frontiers in Sports and Active Living
doi 10.3389/fspor.2026.1992834
Original Research
Published
Integrating Mendelian randomization with single-cell and spatial transcriptomics to investigate gut microbiota-associated genetic signals and molecular characteristics in prostate cancer
Chenjie Qiu · Huilin Zhang · Zongmin Du · Yuan Gao · Liangliang Dai
Frontiers in Cellular and Infection Microbiology
doi 10.3389/fcimb.2026.1899354
Review
Published
Mapping the hepatic neural niche: from three-dimensional innervation architecture to periportal interoception and human translation
Kun Wang · Xiangkun Mei · Hongqiang Gao
Frontiers in Physiology
doi 10.3389/fphys.2026.1955737
Technology and Code
Published
An integrative meningioma surfaceome atlas and a transferable framework for CAR-T target nomination
Vivek Sanker · Dhanya Mahesh · Linda Liverani · Matthew Alexander Abikenari · Zhikai Li · Yi Zhang · Debebe Theodros · Ravi Medikonda · Maria Jose Cavagnaro · Matei Alexandru Banu · Atman Desai · Michael Lim
Frontiers in Bioinformatics
doi 10.3389/fbinf.2026.1919802
Original Research
Published
Gut microbiota disturbance disrupts osteonal organization and mechanical competence during postnatal cortical bone maturation in rabbits with local metabolic and transcriptional remodeling
Xiaopei Yang · Ziming Geng · Hongji Wang · Gongzi Zhang · Shicheng Luo · Binbin Liu · Yansen Wang · Shuwei Zhang · Lihai Zhang
Frontiers in Cell and Developmental Biology
doi 10.3389/fcell.2026.1937899
Original Research
Published
An entosis-informed prognostic index for survival stratification and molecular characterization in lung adenocarcinoma
Yinqin Liu · Wen Zhao · Shuyi Mu · Silun Liang · Yanping Wen · Shaobin Li · Chengyan Zhan · Yanqi Cheng · Ling Tang · Yuqin Wu · Ziyou Lin · Hong Fang · Yubin Ding
Frontiers in Cell and Developmental Biology
doi 10.3389/fcell.2026.1943127
Original Research
Published
Molecular mechanism of dynamic regulation of the proNGF/NGF ratio in controlling hair follicle cycle transition in liaoning cashmere goats
Bing Luo · Di Han · Meng Sun · Jianwei Wei · Mingqian Li · Shuai Chang · Zhiguo Quan · Ying Wang · Chunqiang Wang · Wei Ma
Frontiers in Cell and Developmental Biology
doi 10.3389/fcell.2026.1940416
Original Research
Published
Mechanism of luteolin in treating chronic heart failure by regulating HIF-1 signaling pathway-mediated mitochondrial damage to inhibit cardiomyocyte apoptosis
Weiqi Shi · Zhide Zhu · Junshen Lu · Meiling Tang · Yan Pang · Zhilin Peng · Jie Lu · Puwei Huang · Shanyun Zou · Jiaji Wu · Yarou Tu · Chunmei Fan · Yuyun Gan · Lihui Hu · Qi Lin · Liuqin Qin · Rusheng Shi · Fei Zhong · Yuxuan Shen · Jianqi Lu
Frontiers in Cell and Developmental Biology
doi 10.3389/fcell.2026.1977166
Mini Review
Published
From inherited susceptibility to tumor state: toward a stage-aware architecture for genomic risk stratification in prostate cancer
Ziheng Zheng · Xuechun Yang · Minqian Ou · Yuedong Chen · Deyong Gan
Frontiers in Genetics
doi 10.3389/fgene.2026.1969511
Original Research
Published
Genetic evidence and multi-omics characterization of DEHP-relevant detoxification and metabolic heterogeneity in hepatocellular carcinoma
Zeyang Fan · Guoqing Zhang · Letian Ren · Wence Zhou
Frontiers in Toxicology
doi 10.3389/ftox.2026.1925431
Original Research
Published
Cellular, chromatin-accessibility, and spatial contextualization of bulk transcriptional patterns linked to positive peritoneal cytology in endometrial cancer
Jiangang Huang · Binglai Luo · Zhiqing Hu · Shuping Lin · Jinyong Wang · Meiyan Lin
Frontiers in Genetics
doi 10.3389/fgene.2026.1924936
Review
Published
Decoding endurance performance: integrative genomic and epigenetic insights into the molecular basis of athletic adaptation
Arij El Haddouchi · Amina Marrouh · Souad Kartti · Elmostafa El Fahime · Saber Boutayeb · Younes Chagar · Christophe Baudot · Lahcen Belyamani · Rachid Eljaoudi · Taoufiq Dakka
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1858520
Technology and Code
Published
singIST: an R/bioconductor library and quarto dashboard for automated single-cell comparative transcriptomics analysis of disease models and humans
Aitor Moruno-Cuenca · Sergio Picart-Armada · Alexandre Perera-Lluna · Francesc Fernández-Albert
Frontiers in Genetics
doi 10.3389/fgene.2026.1952333
Original Research
Published
Plasma untargeted metabolomics reveals metabolic signatures associated with epilepsy and anti-seizure medication responsiveness
Zijian Li · Zhen Liang · Juan Ren · Songyan Liu
Frontiers in Molecular Biosciences
doi 10.3389/fmolb.2026.1885513
Original Research
Published
Integrated bioinformatics and single-cell transcriptomics identify mitochondrial dysfunction-driven biomarkers for preeclampsia diagnosis
Lin Lin · Xiaowu Wang · Chengxiu Zhu · Kejun Ye · Dan Zhang · Ruohua Li · Mengjia Peng
Frontiers in Molecular Biosciences
doi 10.3389/fmolb.2026.1922190
Original Research
Published
Multi-omics integration in allergy, viral infections and asthma: a comprehensive analysis of bioinformatics tools
Silvia Garcés Rigol · Nuria Contreras · Rafael Núñez · Elena Izquierdo · Domingo Barber · Alma Villaseñor · Osvaldo Graña Castro · María M. Escribese
Frontiers in Bioinformatics
doi 10.3389/fbinf.2026.1904588
Review
Published
GPCR signaling systems facilitate precision interventions for multi-oncology therapy
Ashley Del Pozo · Mia Pardo · Tabitha Boeringer · Carter J. Craig · Ramzia Sorathia · Madeline Millican · Stuart Maudsley
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1940022
Review
Published
Microbial responses to microgravity and consequences for plant-microbe interactions in space
Daphné Golaz · Marcel Egli · Gabriella Pessi
Frontiers in Astronomy and Space Sciences
doi 10.3389/fspas.2026.1864382
Systematic Review
Published
Research hotspots and emerging trends of macrophages in peripheral nerve injury: a bibliometric and visualization analysis
Guohua Jiang · Renkun Huang · Kewen Wang · Yuchang Gui · Yun Tang · Guiyang Jiang · Yijun Liu · Jianwen Xu
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1893849
Review
Published
Fibroblast-centered mechanisms of chronic inflammation and airway remodeling in allergic bronchopulmonary aspergillosis
Menglin Li · Chenxiao Qiao · Yun Pan · Jintao Zhang · Qian Chen · Ying Wang · Yinghui Qu · Ruichen Du · Shizhen Wang · Qian Qi
Frontiers in Allergy
doi 10.3389/falgy.2026.1952768
Original Research
Published
In silico transcriptomic analysis nominates TSPAN32 as a central node of SCFA-driven immunometabolic reprogramming in intestinal epithelial cells
Zahra Masood · Iqra Sarwar · Ayesha Sanam · Amber Zaidi · Muhammad Zulfiqah Sadikan
Frontiers in Bioinformatics
doi 10.3389/fbinf.2026.1847552
Editorial
Published
Editorial: Integrative single-cell and spatial multiomics: charting cellular architecture and disease microenvironments
Wenchong Chen · Jingjing Lu · Wancheng Guo · Boyu Li · Hang Zhang · Yilin Wang · Zhaokai Zhou · Ran Xu
Frontiers in Bioinformatics
doi 10.3389/fbinf.2026.1983096
Brief Research Report
Published
The circulating metatranscriptome in acute myeloid leukemia patients: an RNA-seq reanalysis
An Dinh Duy Nguyen · Roshan Kern · Tatiana Dombrovski · Thomas LaFramboise
Frontiers in Microbiomes
doi 10.3389/frmbi.2026.1903806
Original Research
Published
Innate immune activation profiles are associated with polarization of the T cell response to recombinant arenaviral vectors
Sarah Szaffich · Valentin Just · Natalija Cvetkovic · Naila Pepic · Michael Schwendinger · Kia Katchar · Klaus K. Orlinger · Henning Lauterbach · Josipa Raguz · Katell Bidet Huang
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1897043
Original Research
Published
Peripheral adaptive immune remodeling associated with severe hearing loss in older adults: a single-center flow-cytometry study with mouse cochlear transcriptomic context
Qunhui Zhang · Wei Liu · Meijun Shao · Jinyu Wang · Qianyi Zhong · Linlan Jiang
Frontiers in Aging
doi 10.3389/fragi.2026.1925166
Review
Published
Integrative multi-omics and network biology in cardiovascular disease: a systems-level framework for translational discovery
Vanesa Brecher · Vasiliki Androutsopoulou · Serge Sicouri · Basel Ramlawi · Dimitrios V. Avgerinos · Thanos Athanasiou · Dimitrios E. Magouliotis
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1897299
Review
Published
Rewriting the brain: m6A RNA methylation as an emerging epitranscriptomic regulator in major depressive disorder
Anuj K. Verma · Hiroaki Mori · Bhaskar Roy · Yogesh Dwivedi
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1922816
Original Research
Published
Conserved storage-carbohydrate metabolic modules are rewired during germination of Trichoderma asperelloides and other Sordariomycetes
Bar Tenennbaum · Elizabeta Yakubovich · Yen-Wen Wang · Guoliang Meng · Soumya Moonjely · Frances Trail · Julius Ben Ari · Zheng Wang · Caihong Dong · Jeffrey Peter Townsend · Oded Yarden
Frontiers in Fungal Biology
doi 10.3389/ffunb.2026.1930613
Review
Published
Exposome influences: a multi-omics perspective on the combined toxic effects of pharmaceuticals and personal care products in Alzheimer’s disease
İ. İpek Boşgelmez · Beyza Mertaş · Hayrunnisa Deliser
Frontiers in Toxicology
doi 10.3389/ftox.2026.1871830