Molecular Biomarkers, Cellular Senescence, and Inflammageing in Biological Ageing: From Mechanisms to Clinical Applications

Biological ageing is a highly heterogeneous process that cannot be captured by chronological age alone. Emerging evidence highlights the central role of molecular and cellular mechanisms, including the accumulation of senescent cells, chronic low-grade inflammation (inflammageing), and shifts in circulating biomarker profiles, in determining an individual’s biological age and vulnerability to age-related disease.This Research Topic seeks to integrate two critical perspectives: the identification and validation of circulating biomarkers capable of predicting frailty and guiding clinical decision-making, and the mechanistic understanding of how cellular senescence and inflammageing drive multimorbidity in older adults. Together, these lenses offer a powerful translational framework, connecting molecular biology to bedside application.We welcome submissions including original research articles, systematic reviews, meta-analyses, and perspective pieces addressing, but not limited to, the following themes:1. Circulating biomarkers of biological age and frailty2. Cellular senescence mechanisms and their systemic consequences3. Inflammageing as a driver of multimorbidity4. Multi-omics approaches to biological age profiling5. Translational models bridging molecular findings to clinical outcomes6. Therapeutic strategies targeting senescence and inflammageing Topic editors: Maria Conte, Stefano Salvioli Source: https://www.frontiersin.org/research-topics/80958/molecular-biomarkers-cellular-senescence-and-inflammageing-in-biological-ageing-from-mechanisms-to-clinical-applications