Sex Differences in Aging

Recent studies increasingly reveal sex-differences in aging and aging-associated disease. For example, across human populations, women consistently exhibit greater life expectancy than men. Critical aging-associated diseases including neurodegenerative disease, obesity, diabetes and cancer show sex-differences in prevalence and/or complications. Modeling, genetic sequencing, and directed evolution experiments support a role for sexual conflict and sexual antagonistic pleiotropy in the evolution of aging. Both sex chromosome content and sex-biased hormone levels are implicated as causal factors in sex-differences in aging. In addition, age of sexual maturation and reproductive history are implicated in modulating aging. Small molecule, dietary and genetic interventions in aging often show sex-biased effects in model systems and in human subjects. As a consequence, sex is increasingly appreciated as an important factor to consider in designing personalized interventions in aging and aging-associated disease. Proposed topics include:Sex hormone effects on agingMenopause and andropause effects in aging Sex differences in immune function in agingRegulation of aging by the gonadSex differences in organ agingSex differences in neurodegenerative diseaseAging of the reproductive systemSex differences in mitochondrial function in agingEffects of mating and reproduction on agingEvolution of sex differences in agingDosage compensation and X inactivation in agingY chromosome loss in agingSex-specific interventions in agingTransgender agingSex by diet interactions in agingSex differences in senescence Topic editors: John Tower, Jianhua Zhang, Laura Haynes, CONSUELO BORRAS, Kieran Reid Source: https://www.frontiersin.org/research-topics/74670/sex-differences-in-aging