Targeting The Hallmarks of Aging to Enhance Stress Recovery and Resilience

The capacity to resist and recover from physiological stress - physical, cognitive, metabolic, or cellular - is one of the most clinically meaningful dimensions of healthy aging. There is a lack of studies examining the measurable outcome: physical function and cognitive performance, and their molecular underpinnings across the lifespan, and the underlying biological mechanisms remain unclear.Emerging evidence indicates that the hallmarks of aging serve as the molecular foundation of resilience. Factors such as mitochondrial dysfunction, cellular senescence, loss of proteostasis, chronic low-grade inflammation, and altered intercellular communication not only accelerate biological aging but also directly impair the body’s capacity to initiate and maintain recovery. As these processes accumulate, the body’s adaptive capacity diminishes, widening the gap between stress and recovery.This research topic aims to address that gap by encouraging basic, translational, and clinical studies. These studies should examine how hallmark biology influences stress recovery and resilience across different tissues and life stages. Additionally, they should explore how geroscience interventions targeting these hallmarks can enhance adaptive capacity and extend healthspan.Topics of interest include, but are not limited to:o Molecular and cellular mechanisms of physical and cognitive resilience in agingo Mitochondrial function and bioenergetics as determinants of recovery capacityo Proteostasis networks and unfolded protein responses under physiological stresso Cellular senescence and its role in blunting adaptive responseso Inflammaging and intercellular communication in resilience and recoveryo Geroscience interventions (exercise, metabolic, nutritional, and pharmacological) targeting hallmarks to enhance stress recoveryo Biomarkers and omics-based approaches to measuring resilience and hallmark burdeno Translational and clinical studies linking hallmark biology to frailty, recovery trajectories, and healthspan Topic editors: Casey Sexton, T. Muhammad, Omprakash Singh Source: https://www.frontiersin.org/research-topics/81094/targeting-the-hallmarks-of-aging-to-enhance-stress-recovery-and-resilience