Understanding accelerated Aging Syndromes to uncover the Biology of Human Aging

Premature aging syndromes encompass a group of rare genetic disorders that mimic the physiological signs and molecular hallmarks of natural aging. These conditions, such as Hutchinson–Gilford progeria syndrome (HGPS) and Werner syndrome, are mainly caused by defects in the nuclear envelope structure and alterations in DNA repair pathways. Over the past decades, research in this field has attracted immense interest, as these syndromes offer an exceptional model to study the mechanisms underlying cellular senescence, genomic instability, and tissue degeneration. Despite major advances in understanding their molecular mechanisms, challenges remain in translating this knowledge into effective clinical interventions and in establishing how insights from these diseases can illuminate broader aspects of normal human aging.Recent studies have explored diverse experimental models to dissect the cellular and molecular mechanisms driving premature aging. Murine and cellular models carrying progeroid mutations have been instrumental in identifying causative mechanisms, such as nuclear lamina disorganization, mitochondrial dysfunction, and impaired DNA repair. These discoveries have spurred the development of multiple intervention strategies, including small molecules targeting protein farnesylation pathways, gene-editing techniques aimed at correcting causal mutations, and systemic treatments designed to alleviate cellular damage. Nevertheless, despite these promising advances, significant gaps persist in understanding disease progression, tissue-specific effects, and patient variability.This Research Topic aims to integrate multidisciplinary perspectives to advance the understanding of premature aging syndromes and stimulate the development of therapeutic interventions and management strategies. By bringing together experimental, translational, and clinical studies, this initiative seeks to identify the key molecular mechanisms of accelerated aging, evaluate potential interventions, and explore connections between pathological and physiological aging processes. It will also serve as a platform for discussing novel methodologies, advanced model systems, and emerging therapies that could shape future research and clinical management of these conditions.To gather further insights into the biology and therapy of progeroid disorders, we welcome contributions addressing, but not limited to, the following themes:o Comparative analyses between premature and physiological aging.o Molecular and cellular mechanisms underlying accelerated aging diseases.o Epigenetic landscape and cellular reprogramming in premature aging and longevity research.o Novel therapeutic frontiers and interventions in progeroid and related syndromes.o Development and characterization of advanced cellular and animal models for the study of progeroid syndromes.o Clinical features and innovations in patient care, management and monitoring of premature aging syndromes. Topic editors: Olaya Santiago Fernández, Magda Rita Hamczyk, Diana Campos-Iglesias Source: https://www.frontiersin.org/research-topics/81140/understanding-accelerated-aging-syndromes-to-uncover-the-biology-of-human-aging