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Frontiers in Genetics ·

Volume 17 - 2026 | https://doi.org/10.3389/fgene.2026.1943337

Correction: GOLPH3 inhibits glioma cell apoptosis through the JNK signaling pathway

  • Shao Xie1,2
  • Jiahai Ding2
  • Zhaohao Wang3
  • Hengliang Shi4
  • Zheng-Quan Yu1*corresponding author
  1. 1Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
  2. 2Department of Neurosurgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China
  3. 3Department of Neurosurgery, Yantaishan Hospital Affiliated to Binzhou Medical University, Yantai, China
  4. 4Central Laboratory, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
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Abstract

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There was a mistake in Figure 4D as published. The p-JNK, GFP, and p-JNK+GFP+DAPI merged images for the shNC group were inadvertently replaced with incorrect source files during figure compilation. The corrected Figure 4D appears below.

Detection of the effect of GOLPH3 on glioma apoptosis *in vivo*. **(A)** Construction of U87 glioma cells stably down-regulating GOLPH3. The proportion of lentiviral infection and the effect after infection are identified using fluorescence and WB experiment. The representative image (left) and immunoblot (right) show that the downregulation of GOLPH3 has a therapeutic effect of over 80%. Scale bar: 100 μm. **(B)** DAPI fluorescence staining was performed using brain slices of intracranial gliomas. Scale bar: 1 mm. **(C)** Quantitative analysis of the volume of intracranial gliomas. **(D)** Representative images of p-JNK staining in tumor brain tissue derived from shNC and shGOLPH3 cells. Scale bar: 20 um. **(E)** Quantitative analysis of the p-JNK positive cells. **(F)** Representative images of cleaved caspase 3 staining in tumor brain tissue derived from shNC and shGOLPH3 cells. Scale bar: 20 um. **(G)** Quantitative analysis of the cleaved caspase 3 positive cells. **(H)** Representative images of TUNEL staining in tumor brain tissue derived from shNC and shGOLPH3 cells. Scale bar: 20 um. **(I)** Quantitative analysis of the TUNEL positive cells.
Figure 1. Detection of the effect of GOLPH3 on glioma apoptosis in vivo. (A) Construction of U87 glioma cells stably down-regulating GOLPH3. The proportion of lentiviral infection and the effect after infection are identified using fluorescence and WB experiment. The representative image (left) and immunoblot (right) show that the downregulation of GOLPH3 has a therapeutic effect of over 80%. Scale bar: 100 μm. (B) DAPI fluorescence staining was performed using brain slices of intracranial gliomas. Scale bar: 1 mm. (C) Quantitative analysis of the volume of intracranial gliomas. (D) Representative images of p-JNK staining in tumor brain tissue derived from shNC and shGOLPH3 cells. Scale bar: 20 um. (E) Quantitative analysis of the p-JNK positive cells. (F) Representative images of cleaved caspase 3 staining in tumor brain tissue derived from shNC and shGOLPH3 cells. Scale bar: 20 um. (G) Quantitative analysis of the cleaved caspase 3 positive cells. (H) Representative images of TUNEL staining in tumor brain tissue derived from shNC and shGOLPH3 cells. Scale bar: 20 um. (I) Quantitative analysis of the TUNEL positive cells.

The original version of this article has been updated.

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Footnotes

Edited and reviewed by: Juanjuan Zhao, Zunyi Medical University, China

Citation

Xie, S., et al. (2026). Correction: GOLPH3 inhibits glioma cell apoptosis through the JNK signaling pathway. Frontiers in Genetics, Volume 17. https://doi.org/
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17 - 2026

Copyright

Copyright © 2026 Xie, Ding, Wang, Shi and Yu.

License: https://creativecommons.org/licenses/by/4.0/

*Correspondence: Zheng-Quan Yu

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