Hypothesis and Theory
Published
Influencing the exposome, patient macroenvironment, tumor microenvironment through-line to improve clinical outcomes
Samuel F. Yanuck · Neil E. Alexis
Frontiers in Oncology
doi 10.3389/fonc.2026.1929067
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Articles
Every article on Frontiers is peer reviewed, permanently archived and free to read.
Showing 50 articles
Systematic Review
Published
Chinese medicine combined with EGFR-TKIs in EGFR-mutated advanced NSCLC: a meta-analysis of efficacy and safety
Xiaohong Li · Die Qian · Shuai Liu · Mingmin Na · Bihong Dai · Chunping Wan
Frontiers in Oncology
doi 10.3389/fonc.2026.1942222
Original Research
Published
Age-stratified survival and competing mortality in adult acute lymphoblastic leukemia and lymphoblastic lymphoma: a population-based competing-risk and restricted mean survival analysis
Zhe Li · Jianglin Yu
Frontiers in Oncology
doi 10.3389/fonc.2026.1913564
Original Research
Published
Global and registry-based patterns of pancreatic cancer: GLOBOCAN 2020, CI5plus trends (2000–2017), and demographic projections to 2040
Xin Jin · Xiao Guan · Yongrun Mu · Min Wang · Chengfeng Wang
Frontiers in Oncology
doi 10.3389/fonc.2026.1850604
Review
Published
Spatial architecture shapes programmed cell death-associated immune niches and therapeutic resistance in clear cell renal cell carcinoma
Yu Yin · Junlong Wang · Dengxiong Li · Dandan Qiu
Frontiers in Oncology
doi 10.3389/fonc.2026.1952158
Review
Published
De-escalation of axillary surgery in clinically node-negative (cN0) breast cancer: current evidence, advances, and controversies
Jinxiu Ma · Meizi Cui · Dongqing Li · Sijia Wang · Jian Sun · Hao Guo · Yingying Ding · Zhimin Fan · Xiaozhen Wang
Frontiers in Oncology
doi 10.3389/fonc.2026.1971201
Original Research
Published
Definitive radiotherapy versus surgery after neoadjuvant immunochemotherapy for locally advanced esophageal squamous cell carcinoma: a propensity score-matched study of efficacy and safety
Qiuying An · Yage Jia · Menglu Liu · Liyuan Fu · Jingxin Bai · Zihan Zhang · Jin Yan · Yajing Wang · Hongshan Ji · Yuhao Su · Ping Zhang · Zhiguo Zhou
Frontiers in Oncology
doi 10.3389/fonc.2026.1885302
Original Research
Published
Risk factors associated with colorectal adenomas and the formulation of prediction models
Haoming Yu · Zongyu Qiu · Wenyao Sui · Shengyu Han · Jihong Li · Wenhua Lan · Xuan Sun · Yuhua Chi
Frontiers in Oncology
doi 10.3389/fonc.2026.1894239
Systematic Review
Published
Imaging biomarkers related to 18F-FDG PET/CT for predicting microvascular invasion in hepatocellular carcinoma: a systematic review and meta-analysis
Zhigang Li · Ke Gong · Ning Liu
Frontiers in Oncology
doi 10.3389/fonc.2026.1948193
Case Report
Published
Natural history and literature review of primary intracranial CIC-rearranged sarcomas: case report
Arissa Khan · Maryam Khan · Abigail Bowser · Sahara Cathcart · Nicole Shonka · Sean Kelly · Daniel Surdell · Breann Bowar · Danielle Cunningham · Qateeb Khan
Frontiers in Oncology
doi 10.3389/fonc.2026.1958689
Original Research
Published
Baseline growth kinetics of pulmonary metastases in head and neck adenoid cystic carcinoma: analysis of correlated clinical and molecular factors
Hong-fei Liu · Ling-yan Jiang · Ting-yao Ma · Yue Zhao · Tian-yi Li · Xue-lian Wang · Shu-jing Zhang · Guo-liang Yang · Jing Zhou · Zhong-yu Yan · Xiao-hong Chen
Frontiers in Oncology
doi 10.3389/fonc.2026.1811232
Original Research
Published
Beyond binary: a novel anatomical-geographical-biological framework for perineural invasion risk stratification in oral squamous cell carcinoma – a proof-of-concept study
Shanthi Velusamy · Prajwal Dange · Karthik N. Rao · Teertha Shetty · Nethra R. · Rekha V. Kumar · Karthik S. Rishi · Aruna Korlimarla · Srinath B.S. · Sreeram M.P.
Frontiers in Oncology
doi 10.3389/fonc.2026.1897905
Mini Review
Published
Arsenic trioxide-induced cardiotoxicity: insights into the oxidative stress-inflammation positive feedback loop, translational biomarkers and targeted cardioprotective strategies— a narrative review
Haiyan Wu · Jian Lv · Xiaoyang Hu
Frontiers in Oncology
doi 10.3389/fonc.2026.1954263
Original Research
Published
Early-onset colorectal cancer burden in China from 1990 to 2023: a systematic analysis based on the Global Burden of Disease Study 2023
Haijian Wei · Hao Wu · Shuai Wang · Yiwei Yao · Kaiwen Zheng · Zhini Yang · Jianan Ma
Frontiers in Oncology
doi 10.3389/fonc.2026.1958227
Original Research
Published
Clinical outcomes and prognostic factors in pediatric acute myeloid leukemia with monocytic differentiation: a single-center cohort study from Egypt
Tarek Ahmed Abdelrehim Ahmed · Mahmoud Hammad · Sonya Soliman · Nahla Elsharkawy · Sherine Ibrahim Salem · Sonia Ahmed · Alaa Elhaddad
Frontiers in Oncology
doi 10.3389/fonc.2026.1969723
Original Research
Published
Association of HER2, p53, and lymphovascular space invasion with lymph node metastasis in endometrial cancer: a retrospective cohort study
Xuqing Cai · Yuanyuan Zhu · Siying Wang · Lingling Gao · Dan Lu
Frontiers in Oncology
doi 10.3389/fonc.2026.1974528
Hypothesis and Theory
Published
Treating a systemic disease as a local one: failure points of current pancreatic cancer management and a multimodal, biology-guided framework for redesign
Patrick E. Sewell
Frontiers in Oncology
doi 10.3389/fonc.2026.1941793
Review
Published
Obesity-driven inflammation and immune dysregulation in cancer development and progression
Pritika Pandey · Jeb F. Struder · Erika T. Rezeli · Evan M. Paules · Stephen D. Hursting · Michael F. Coleman · Kristin A. Altwegg
Frontiers in Oncology
doi 10.3389/fonc.2026.1947958
Perspective
Published
From macrofungal polysaccharides to precision microbial immunotherapy: reprogramming the tumor microenvironment through immunometabolic and gene-regulatory pathways
Kingsley Excel Dunga · Sylvester Chibueze Izah · Ebinyo Rebecca Aseibai · Matthew Chidozie Ogwu · Vivian Ibienebakabobo Promise · Nsikak Godwin Etim · Irene Nneka Ohanusi
Frontiers in Oncology
doi 10.3389/fonc.2026.1966586
Original Research
Published
Cross-lagged panel analysis of kinesiophobia and frailty in older patients undergoing radical prostatectomy
Yue Gu · Hang Liu · TingYao Nie · YaNan Guo · Rui Yang · Ying Li · KeXin Zhao
Frontiers in Oncology
doi 10.3389/fonc.2026.1914051
Clinical Trial
Published
Preliminary evaluation of ProSpare ® , a rectal obturator for prostate bed radiotherapy within the randomised multicentre POPS trial (NCT02978014)
Sarah Stewart · Karen Thomas · Jenni Parmar · Alison Claire Tree · Chris Parker · Helen McNair · Sophie Alexander · Julia Henderson · James Talbot · Christopher Scrase · Chee Goh · Reena Davda · Emma Gray · Peter Hoskin · Sarah Needleman · Jenny Nobes · Kamalram Thippu Jayaprakash · Yvonne Rimmer · Ranachandran Venkitaraman · Anna Wilkins · Vincent Khoo · Julia Murray · David Paul Dearnaley
Frontiers in Oncology
doi 10.3389/fonc.2026.1758462
Original Research
Published
A real-world nomogram integrating predictive markers for disease-free survival in postmenopausal triple-negative breast cancer receiving anthracycline/taxane-based chemotherapy
Yan Lin · Shao-hong Yu · Chai-Ming Zeng · Shuang-long Cai · Lei Han
Frontiers in Oncology
doi 10.3389/fonc.2026.1904801
Perspective
Published
Resistance in the edges: a relational framework for treatment resistance in genitourinary cancers
Daniele Silva Lacerda · Rosiane Batista Mastelari · Tiago Veiras Collares
Frontiers in Oncology
doi 10.3389/fonc.2026.1974982
Original Research
Published
Development and validation of a nomogram for predicting chest drainage after CT-guided percutaneous lung biopsy: a multicenter retrospective study
Haiyu Liang · Yanyan Tang · Weicong Kang · Yanfeng Zhao
Frontiers in Oncology
doi 10.3389/fonc.2026.1930072
Perspective
Published
Revisiting proton therapy for adenoid cystic carcinoma: a case worth making
Astha Rohit · Adam Holtzman · James Bates · Scott Lester · Roi Dagan · Barbara Vischioni · Ester Orlandi · Maria Bonora · Amy Tien Yee Chang · Rohan Deraniyagala · Martin Bues · Steven Frank · Samir H. Patel · Atsushi Musha · Tatsuya Ohno · Nancy Lee · Lisa McGee
Frontiers in Oncology
doi 10.3389/fonc.2026.1979803
Case Report
Published
Case Report: From unresectable to resectable: successful conversion therapy with TACE, HAIC, envafolimab, and olaparib in advanced intrahepatic cholangiocarcinoma
Chi Ma · Kun Feng · Jun Zhou
Frontiers in Oncology
doi 10.3389/fonc.2026.1935499
Original Research
Published
Multi-cohort screening of PANoptosis-related genes reveals PARP1 as a key target, and AZD5305 exerts anti-tumor effects in neuroblastoma
Shujun Shi · Zhaoxia Zhang · Junyi Luo · Zhaoying Wang · Tao Mi · Liming Jin · Xiangpan Kong · Jinkui Wang · Junhong Liu · Li Wang · Dawei He
Frontiers in Oncology
doi 10.3389/fonc.2026.1903085
Case Report
Published
Multiple sclerosis relapse following gamma knife radiosurgery for meningioma in a patient treated with natalizumab: case report
Maryna Turbinska · Nabeela Nathoo · Penelope Smyth
Frontiers in Oncology
doi 10.3389/fonc.2026.1959731
Original Research
Published
Functional ovarian reserve in women with Hodgkin and non-Hodgkin lymphomas
Francesca Filippi · Nicole Serra · Sabrina Comana · Giorgia Di Stefano · Marco Reschini · Paola Vigano’ · Edgardo Somigliana
Frontiers in Oncology
doi 10.3389/fonc.2026.1965843
Case Report
Published
Durable partial response with low-dose, intermittent nivolumab in combination with gemcitabine for high PD-L1 metastatic triple-negative breast cancer: a case report
Po Lin Ooi · Jamin Munchar Elias · Francis Yew Fu Tieng
Frontiers in Oncology
doi 10.3389/fonc.2026.1964934
Original Research
Published
Comparison of feasibility, inter-instrument agreement, and prognostic value of four frailty assessment instruments in geriatric colorectal cancer patients: a 3-year multicenter prospective cohort study
Lei Ma · Feiyu Shi · Chenhao Hu · Kexue Wang · Lei Zhang · Penghong Qu · Junjun She
Frontiers in Oncology
doi 10.3389/fonc.2026.1878424
Original Research
Published
A large animal lung cancer model for the evaluation of intratumoural cisplatin delivery strategies
James Meehan · David Collie · Ziyuan Chang · Rachael Gregson · R. Eddie Clutton · Stephen N. Greenhalgh · Lynn Grant · Sara Kennedy · James Nixon · Chris Cousens · Helen Todd · Jennifer Savage · Jo Moore · David J. Griffiths · Lorna J. Eades · Gavin Sim · Nicole Storer · Chad E. Eckert · Mark Gray
Frontiers in Oncology
doi 10.3389/fonc.2026.1906629
Original Research
Published
Cytarabine-based mobilisation yields higher CD34+ cell counts than cyclophosphamide regardless of prior daratumumab exposure in multiple myeloma
Wojciech Szlasa · Artur Borkowski · Monika Mordak-Domagała · Jacek Kwiatkowski · Katarzyna Malesa · Mateusz Sawicki · Jarosław Dybko
Frontiers in Oncology
doi 10.3389/fonc.2026.1915658
Original Research
Published
EQD2-adjusted mean lung dose and symptomatic pneumonitis after thoracic radiotherapy following immune checkpoint inhibitors in lung cancer: a single-center retrospective cohort study
Xiqing Li · Libin Liu · Nuo Zheng · Nila Wang · Tingxiong Xiao · Xiaolong Lin · Haidun Chen · Qin Shi · Yuyin Le
Frontiers in Oncology
doi 10.3389/fonc.2026.1923622
Correction
Published
Correction: Trends in cervical cancer incidence and mortality in Mongolia, 2014–2024: a population-based analysis of pandemic-related disruptions
Frontiers Production Office
Frontiers in Oncology
doi 10.3389/fonc.2026.1993185
Original Research
Published
Tumor-antigen-specific polyclonal antibodies suppress tumor growth and metastasis in heterogeneous solid tumors
Carine Ciron · Ophélie Dauphouy · Pierre Morice · Pierre-Joseph Royer · Gwenaëlle Evanno · Juliette Rousse · Françoise Shneiker · Bernard Vanhove · Odile Duvaux · Firas Bassissi
Frontiers in Oncology
doi 10.3389/fonc.2026.1947593
Original Research
Published
Study on the promoting effect of microplastic exposure on prostate cancer migration and invasion based on network toxicology and single-cell sequencing technology
Haiyang Jiang · Ying Bi · Longguo Dai · Yong Zhu · Ruikang Zhang · Chen Hu · Hong Yang · Jun Li · Chongjian Zhang · Yu Bai · Ruiqian Li
Frontiers in Oncology
doi 10.3389/fonc.2026.1973812
Original Research
Published
From armed-conflict to care: clinical outcomes, diagnostic challenges, and psychosocial burden in children evaluated for suspected cancer displaced from Gaza and treated at a regional center of excellence
Rawad Rihani · Shrouq Amer · Maha Barbar · Omar Shamieh · Arwa Kiswani · Richard Sullivan · Carlos Rodriguez-Galindo · Asem Mansour
Frontiers in Oncology
doi 10.3389/fonc.2026.1934075
Case Report
Published
Durable biochemical and radiographic response during toripalimab treatment in MSI-high/TMB-high mCRPC: a case report
Junhang Ding · Zhengxin Liu · Jinyu Tian · Feng Wang · Chuan Liu
Frontiers in Oncology
doi 10.3389/fonc.2026.1907524
Case Report
Published
Case Report: Ribociclib-associated bilateral neurotrophic keratitis requiring amniotic membrane transplantation during adjuvant treatment of early breast cancer
Danielle DeCicco · Sanjana Nethagani · Lingo Lai · Danish Safi
Frontiers in Oncology
doi 10.3389/fonc.2026.1932226
Review
Published
Liquid biopsy in pancreatic ductal adenocarcinoma from diagnostic accuracy to clinical utility
Konstantinos Kossenas · Nikolaos Garmpis · Nikolaos Karountzos · Christos Damaskos
Frontiers in Oncology
doi 10.3389/fonc.2026.1962181
Review
Published
Genesis—progression of early jaw osteoradionecrosis in head and neck cancer survivors: dynamics of independent but interconnected factors
Sylvie E. Delanian
Frontiers in Oncology
doi 10.3389/fonc.2026.1941783
Original Research
Published
Total body irradiation practice patterns: insights from a national survey
Zaheeda Mulla · Ali Balbaid · Ghada Aldosary · Wsam Ghandourh · Ismail AlDahlawi · Mohamed Bayoumy · Mohannad Alhumaid · Fahad Alrowais · Hussain Almerdhemah · Hiba Taha · Abdullah AlMohamad · Wasil Jastaniah
Frontiers in Oncology
doi 10.3389/fonc.2026.1960445
Original Research
Published
Barriers and facilitators to symptom-related help-seeking among men with genitourinary malignancies: a qualitative study
Rong Liu · Xiang Xi · Xiao Ma · Yu Zhao · Hui Zhuo
Frontiers in Oncology
doi 10.3389/fonc.2026.1915743
Review
Published
From image biomarkers to treatment decisions: multimodal AI and clinical translation in gynecologic oncology
Mohamad Bakir · Mohammad Khaldoun Al Masri · Yousef Mushtaha · Narmeen Shaikh · Mohammed Raddaoui · Khalid Said Mohammad
Frontiers in Oncology
doi 10.3389/fonc.2026.1960963
Correction
Published
Correction: Real world genomic profiling in non-small cell lung cancer reveals regional variations with clinical implications
Frontiers Production Office
Frontiers in Oncology
doi 10.3389/fonc.2026.2013767
Review
Published
Nodal evaluation as the arbiter of oncologic equivalence: reassessing segmentectomy after CALGB 140503 and JCOG0802
Akbar Bazarbaev · Vasiliki Androutsopoulou · Prokopis-Andreas Zotos · Namariq Abbaker · Marco Scarci · Dimitrios E. Magouliotis
Frontiers in Oncology
doi 10.3389/fonc.2026.1986814
Opinion
Published
The N2 dilemma in stage III NSCLC: toward a quantitative framework for trial design
Luca Bertolaccini · Monica Casiraghi · Antonio Mazzella · Giorgio Lo Iacono · Lorenzo Spaggiari
Frontiers in Oncology
doi 10.3389/fonc.2026.1866606